Bachratá M, Bezáková Z, Knazko L, Subert J
Pharmazie. 1977 Jul 7;32(7):398-401.
The possibility and conditions of determination of weak acid type medicaments were examined, using aqueous and non-aqueous sodium borohydride volumetric solutions. The process and control of titration were carried out potentiometrically and visually using acido-basic indicators. It was shown that for practical applications sodium borohydride aqueous solutions are more suitable. Analytical methods of determination for medicaments from the group of sulphonamides and barbiturates and their sodium salts, for phenylbutazone and kebuzone, salicylamide, nalidixic acid and theophylline were elaborated. All results were in good agreement with methods used in CsL 3, or other alternative methods. The advantages of the proposed method are good stability of sodium borohydride volumetric solution and insensitivity of titrated systems to CO2 from the atmosphere, which is unavoidable with alkalimetric titrations in aqueous and non-aqueous systems. An hypothesis has been suggested to explain the probable reactive mechanism of determination, supported by results obtained with the proposed analytical methods using a medium of suitable organic solvents with a maximum content of ca. 15% water near the final point of titration.
使用硼氢化钠水溶液和非水溶液体积溶液，研究了测定弱酸型药物的可能性和条件。滴定过程和控制通过电位法和使用酸碱指示剂进行目视检测。结果表明，对于实际应用，硼氢化钠水溶液更合适。阐述了磺胺类、巴比妥类及其钠盐、保泰松、凯布宗、水杨酰胺、萘啶酸和茶碱等药物的分析测定方法。所有结果与CSL 3中使用的方法或其他替代方法吻合良好。所提出方法的优点是硼氢化钠体积溶液稳定性好，滴定体系对大气中的二氧化碳不敏感，这在水溶液和非水溶液体系的碱量滴定中是不可避免的。有人提出了一个假设来解释可能的测定反应机制，该假设得到了在滴定终点附近使用含水量最高约15%的合适有机溶剂介质的所提出分析方法获得的结果的支持。
