Benn P A, Harnden D G, Fairburn E A
J Natl Cancer Inst. 1978 Jan;60(1):45-50. doi: 10.1093/jnci/60.1.45.
Fibroblast cultures were grown from skin biopsy specimens from individuals with a high risk of cancer due to occupational exposure to mineral oil. A high frequency of chromosomally abnormal fibroblast subpopulations was found in cultures derived from tissue that had been exposed to the carcinogen, but these aberrant clonal populations were also present in control lines from the same individuals. Abnormal clones formed a greater proportion of the total cell population in the lines derived from the oil-exposed tissue compared with the control lines after a comparable time in culture. This difference in clone size may be a consequence of the in vivo exposure to mineral oil or other environmental agents.
成纤维细胞培养物来自因职业接触矿物油而患癌风险较高的个体的皮肤活检标本。在源自暴露于致癌物的组织的培养物中发现了高频染色体异常的成纤维细胞亚群，但这些异常克隆群体也存在于来自同一患者的对照细胞系中。与在相同培养时间后的对照细胞系相比，在源自油暴露组织的细胞系中，异常克隆在总细胞群体中所占比例更大。克隆大小的这种差异可能是体内接触矿物油或其他环境因素的结果。
