Järvholm B, Easton D
Department of Occupational Medicine, Sahlgren University Hospital, Göteborg, Sweden.
Br J Cancer. 1990 Dec;62(6):1039-41. doi: 10.1038/bjc.1990.435.
The relationship between skin tumours in man and exposure to polyaromatic hydrocarbons has been studied in lathe operators exposed to cutting oils. Seven cases of scrotal cancer and 13 cases of senile keratosis and keratoacanthoma were observed. The risk varied as the 1.6th power of duration of exposure for cancer on the scrotum and the 2.4th power for tumours on the hand and forearms. These results accord well with experiments on animals. There was some evidence of an increasing trend in risk with increasing age at first exposure.
对接触切削油的车床操作人员中人类皮肤肿瘤与多环芳烃暴露之间的关系进行了研究。观察到7例阴囊癌以及13例老年角化病和角化棘皮瘤。阴囊癌风险随暴露时长的1.6次方变化，手部和前臂肿瘤风险随暴露时长的2.4次方变化。这些结果与动物实验结果高度吻合。有证据表明，首次暴露时年龄越大，风险呈上升趋势。
