Lefevre J
Sem Hop. 1982 Feb 18;58(7):411-3.
Menopausal complaints, especially hot flushes, are common occurrences. Until now, no effective treatment was available for patients in whom estrogens are contraindicated. A trial of veralipride was carried out in ten symptomatic menopausal women (7 physiologic menopauses, 3 surgical menopauses). Symptoms included severe hot flushes, anxiety (N = 6), depression (N = 4), irritability (N = 3), and cephalalgia (N = 2). Patients were given one tablet of veralipride each day for twenty day periods. Effectiveness on hot flushes was excellent in six patients, satisfactory in two, mediocre in one, and null in one. Depression, anxiety, and, to a lesser extent, cephalalgia and irritability, were alleviated. No clinical or biological adverse side-effects were recorded.
更年期不适，尤其是潮热，是常见现象。到目前为止，对于雌激素禁忌的患者尚无有效的治疗方法。对10名有症状的更年期女性（7例生理性绝经，3例手术绝经）进行了维拉必利试验。症状包括严重潮热、焦虑（6例）、抑郁（4例）、易怒（3例）和头痛（2例）。患者每天服用1片维拉必利，持续20天。6例患者潮热症状改善极佳，2例满意，1例一般，1例无效。抑郁、焦虑以及在较小程度上的头痛和易怒症状得到缓解。未记录到临床或生物学不良反应。
