Whitehouse B J, Vinson G P, Thody A J
Steroids. 1982 Feb;39(2):155-64. doi: 10.1016/0039-128x(82)90083-6.
Bromocriptine treatment in rats (3 mg/kg per day, 7 days) significantly reduced alpha-msh and aldosterone plasma levels 2 hrs after the final treatment in animals on low, normal and high sodium diets. Alpha-MSH dose response curves for corticosterone and 18-hydroxydeoxycorticosterone (18-OH-DOC) in subsequently incubated glomerulosa cells gave stimulation at lower concentrations of alpha-MSH (10(-10) moles per litre) than in cells from untreated animals (10(-9) moles per 1). Curves for aldosterone (ald) and 18-hydroxycorticosterone (18-OH-B) were also affected in cells from animals on a low sodium diet. Fasciculata-reticularis cell responses to ACTH were unaffected. Metoclopramide (4 mg/kg per day, 7 days) elevated plasma alpha-MSH, although ald was unaffected, but inhibited the glomerulosa cell response to alpha-MSH in vitro. Acute dopaminergic responses in plasma ald may be mediated through alpha-MSH in rats, but chronically alpha-MSH may down- regulate glomerulosa cell alpha-MSH receptors. It is unlikely that alpha-MSH mediates the adrenocortical response to sodium depletion.
对大鼠进行溴隐亭治疗（每天3毫克/千克，共7天）后，在低钠、正常钠和高钠饮食的动物中，末次治疗2小时后，其血浆α-促黑素（alpha-msh）和醛固酮水平显著降低。在随后孵育的肾小球细胞中，皮质酮和18-羟脱氧皮质酮（18-OH-DOC）的α-促黑素剂量反应曲线显示，与未治疗动物的细胞相比，在较低浓度的α-促黑素（每升10^(-10)摩尔）时就出现了刺激作用。低钠饮食动物的细胞中，醛固酮（ald）和18-羟皮质酮（18-OH-B）的曲线也受到影响。束状带-网状带细胞对促肾上腺皮质激素（ACTH）的反应未受影响。甲氧氯普胺（每天4毫克/千克，共7天）可使血浆α-促黑素升高，虽然醛固酮未受影响，但在体外可抑制肾小球细胞对α-促黑素的反应。血浆醛固酮的急性多巴胺能反应可能通过大鼠体内的α-促黑素介导，但长期来看，α-促黑素可能会下调肾小球细胞的α-促黑素受体。α-促黑素不太可能介导肾上腺皮质对钠缺乏的反应。
