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Structure-activity studies with ACTH/alpha-MSH fragments on corticosteroid secretion of isolated zona glomerulosa and fasciculata cells.

作者信息

Szalay K S, De Wied D, Stark E, Folly G

出版信息

Regul Pept. 1985 Jul;11(3):187-92. doi: 10.1016/0167-0115(85)90049-7.

DOI:10.1016/0167-0115(85)90049-7
PMID:2997858
Abstract

The steroidogenic action of ACTH/alpha-MSH fragments was studied on isolated zona glomerulosa and zona fasciculata cells dispersed by collagenase. ACTH-(4-7), ACTH-(6-10), ACTH-(4-10) and ACTH-(11-13) stimulated corticosterone production of the zona fasciculata and aldosterone production of the zona glomerulosa cells. ACTH-(7-10) was ineffective. ACTH-(4-7) appeared to be the most potent peptide of the tested fragments. None of the fragments affected the steroidogenic action of ACTH-(1-39). It is suggested that similar to the melanotropic effect of alpha-MSH two 'message' sequences for adrenocortical stimulation exist in the alpha-MSH part of the ACTH molecule.

摘要

相似文献

1
Structure-activity studies with ACTH/alpha-MSH fragments on corticosteroid secretion of isolated zona glomerulosa and fasciculata cells.
Regul Pept. 1985 Jul;11(3):187-92. doi: 10.1016/0167-0115(85)90049-7.
2
alpha-MSH and zona glomerulosa function in the rat.α-促黑素细胞激素与大鼠球状带功能
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6
Effects of ACTH-(11-24) on the corticosteroid production of isolated adrenocortical cells.
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Effect of alpha-MSH on the corticosteroid production of isolated zona glomerulosa and zona fasciculata cells.
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8
Long-term trophic action of alpha-melanocyte-stimulating hormone on the zona glomerulosa of the rat adrenal cortex.
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