长期摄入滴滴涕对大鼠的影响。

Effects of long-term intake of DDT on rats.

作者信息

Cabral J R, Hall R K, Rossi L, Bronczyk S A, Shubik P

出版信息

Tumori. 1982 Feb 28;68(1):11-7. doi: 10.1177/030089168206800103.

DOI:10.1177/030089168206800103

Abstract

DDT is a pesticide used in malaria-control programmes throughout the world. Its potential carcinogenicity was studied in MRC Porton rats (Wistar-derived) which received dietary concentrations of 0, 125, 250 and 500 parts per million DDT (technical-grade) for life. The treatment had no adverse effects on body growth or survival rate. Various types of tumours were observed in animals in all groups: exposure to DDT resulted in statistically significant increased incidence of liver-cell tumours only in female treated rats; one such tumour was observed in control rats. No metastases of these tumours were found.

摘要

滴滴涕是一种在全球疟疾防控项目中使用的杀虫剂。在医学研究委员会波顿大鼠（源自Wistar大鼠）中对其潜在致癌性进行了研究，这些大鼠终生摄入浓度分别为百万分之0、125、250和500的滴滴涕（工业级）。该处理对身体生长或存活率没有不良影响。在所有组的动物中都观察到了各种类型的肿瘤：接触滴滴涕仅导致雌性受试大鼠肝细胞肿瘤的发生率在统计学上显著增加；在对照大鼠中观察到了1例此类肿瘤。未发现这些肿瘤有转移情况。