Foran J A, Cox M, Croxton D
Great Lakes Natural Resource Center, National Wildlife Federation, Ann Arbor, MI 48104.
Am J Public Health. 1989 Mar;79(3):322-5. doi: 10.2105/ajph.79.3.322.
Because Great Lakes sport fish are contaminated with several toxicants, the Great Lakes states individually issue advisories, principally based on Food and Drug Administration (FDA) action levels, that suggest limiting or eliminating consumption of contaminated fish. We describe the procedures the states use to determine when to issue consumption advisories and we evaluate the associated cancer risks using EPA-IARC-OSTP risk assessment procedures. Projected cancer risks are high for consumers of small quantities of sport fish contaminated with DDT or dieldrin at their respective action levels. Projected risks at concentrations that are common but below the action levels are also substantial. We propose that sport fish with tissue concentrations of DDT or dieldrin one-fifth and one-third of the action levels should be covered by consumption advisories to warn consumers of the potential adverse health impacts.
由于五大湖的食用鱼受到多种有毒物质的污染，五大湖州各自发布了主要基于美国食品药品监督管理局（FDA）行动水平的建议，建议限制或避免食用受污染的鱼类。我们描述了各州用于确定何时发布食用建议的程序，并使用美国环境保护局-国际癌症研究机构-总统科学技术政策办公室（EPA-IARC-OSTP）风险评估程序评估了相关的癌症风险。对于食用各自行动水平下受滴滴涕（DDT）或狄氏剂污染的少量食用鱼的消费者而言，预计癌症风险很高。在常见但低于行动水平的浓度下，预计风险也很大。我们建议，食用建议应涵盖组织中滴滴涕或狄氏剂浓度分别为行动水平五分之一和三分之一的食用鱼，以警告消费者潜在的健康不良影响。
