Guerri C
Biochem Pharmacol. 1982 Feb 1;31(3):449-53. doi: 10.1016/0006-2952(82)90197-6.
During 7 days of lithium administration to rats, the levels of adenylate cyclase bound to brain synaptosomes decreased, while those of acetylcholinesterase increased. Both enzyme levels returned to their initial values after 1 month of treatment. Monoamine oxidase, which is bound to a mitochondrial membrane, was not affected by lithium treatment. Arrhenius plots of the brain synaptosomal enzymes (Na + K)ATPase and acetylcholinesterase from rats treated with LiCl for 7 or 30 days showed a lower transition temperature. Also, when these synaptosomal enzymes were exposed to such exogenous agents as detergents or alcohol, the reaction of the enzymes obtained from lithium treated rats was different than that of control rats. These effects disappeared after ceasing lithium administration for one week. These data indicate changes in the structure of brain membranes after lithium administration.
在给大鼠施用锂的7天期间，与脑突触体结合的腺苷酸环化酶水平降低，而乙酰胆碱酯酶水平升高。治疗1个月后，两种酶的水平均恢复到初始值。与线粒体膜结合的单胺氧化酶不受锂治疗的影响。用LiCl处理7天或30天的大鼠脑突触体酶（Na + K）ATP酶和乙酰胆碱酯酶的阿伦尼乌斯图显示出较低的转变温度。此外，当这些突触体酶暴露于去污剂或酒精等外源试剂时，从锂处理大鼠获得的酶的反应与对照大鼠不同。停止施用锂一周后，这些效应消失。这些数据表明施用锂后脑膜结构发生了变化。
