在乳铁蛋白存在的情况下，黄嘌呤-黄嘌呤氧化酶反应增强了羟自由基的产生。
Enhanced production of hydroxyl radicals by the xanthine-xanthine oxidase reaction in the presence of lactoferrin.
作者信息
Bannister J V, Bannister W H, Hill H A, Thornalley P J
出版信息
Biochim Biophys Acta. 1982 Mar 15;715(1):116-20. doi: 10.1016/0304-4165(82)90056-3.
The generation of hydroxyl radicals by the xanthine-xanthine oxidase reaction (C. Beauchamp and I. Fridovich (1970) J. Biol. Chem. 245, 4641-1616) has been shown to be increased by iron-saturated lactoferrin isolated from pig neutrophils. Hydroxyl radical production, measured by EPR spin trapping and by ethylene production from alpha-keto-gamma-methiol butyric acid, has been demonstrated to be produced by a Fenton-type Haber-Weiss reaction catalysed by lactoferrin. The possibility that lactoferrin catalyses such a reaction in vivo is considered.
从猪嗜中性粒细胞中分离出的铁饱和乳铁蛋白已被证明可增加黄嘌呤 - 黄嘌呤氧化酶反应（C. 博尚普和I. 弗里多维奇（1970年）《生物化学杂志》245卷，4641 - 1616页）产生的羟自由基。通过电子顺磁共振自旋捕获以及α - 酮 - γ - 甲硫基丁酸产生乙烯的方法测量到的羟自由基生成，已被证明是由乳铁蛋白催化的芬顿型哈伯 - 韦斯反应产生的。文中考虑了乳铁蛋白在体内催化此类反应的可能性。
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