Sharp A M, Handelsman D J, Ristuccia R M, Turtle J R
Clin Chem. 1982 Jun;28(6):1333-4.
To investigate the potency of dexamethasone in suppressing adrenocortical function, we gave various evening doses to laboratory staff members. Plasma corticotropin, cortisol, and dehydroepiandrosterone sulfate concentrations were measured the following day, to quantitate the degree of suppression after both short- and long-term treatments. We found that the minimum amount for effective suppression was 1 mg for a single evening dose, 0.5 mg per day for a long-term evening dose. On these regimens plasma corticotropin and cortisol were consistently suppressed, but plasma dehydroepiandrosterone sulfate was suppressed only with long-term treatment.
为研究地塞米松抑制肾上腺皮质功能的效力，我们给实验室工作人员服用了不同的晚间剂量。次日测量血浆促肾上腺皮质激素、皮质醇和硫酸脱氢表雄酮浓度，以定量短期和长期治疗后的抑制程度。我们发现，单次晚间有效抑制的最小剂量为1毫克，长期晚间剂量为每日0.5毫克。在这些方案下，血浆促肾上腺皮质激素和皮质醇持续受到抑制，但仅长期治疗能抑制血浆硫酸脱氢表雄酮。
