Ryan J P, Pellecchia D
Gastroenterology. 1982 Jul;83(1 Pt 1):81-3.
Experiments were designed to examine the effect of chronic pretreatment with progesterone (2 mg/kg . day for 5 days) on the in vitro contractile response of gallbladder muscle strips from adult male guinea pigs. The muscle strips were challenged with either acetylcholine or the octapeptide of cholecystokinin and dose-response relationships were determined. The data were compared with dose-response curves obtained from untreated control animals. progesterone pretreatment produced right-ward shifts in the acetylcholine and octapeptide of cholecystokinin curves that were characterized by significant decreases in the maximal contractile response. Serum progesterone concentrations in the pretreated animals were significantly increased over control levels. The data support the hypothesis that the sluggish behavior of the gallbladder during pregnancy and during the luteal phase of the menstrual cycle may be due, in part, to progesterone-related alterations in the contractile properties of gallbladder smooth muscle.
实验旨在研究孕激素（2毫克/千克·天，连续5天）长期预处理对成年雄性豚鼠胆囊肌条体外收缩反应的影响。用乙酰胆碱或胆囊收缩素八肽刺激肌条，并确定剂量-反应关系。将数据与未处理的对照动物获得的剂量-反应曲线进行比较。孕激素预处理使乙酰胆碱和胆囊收缩素八肽曲线向右移位，其特征是最大收缩反应显著降低。预处理动物的血清孕激素浓度明显高于对照水平。这些数据支持以下假设：妊娠期间和月经周期黄体期胆囊的迟缓行为可能部分归因于孕激素相关的胆囊平滑肌收缩特性改变。
