Levo Y
Int Arch Allergy Appl Immunol. 1982;68(2):179-81. doi: 10.1159/000233091.
Fibronectin (FN) has been implicated in the cryoprecipitation of fibrin-fibrinogen complexes. Preliminary observations have suggested that it may also play a role in cryoglobulinemia. In the present study 32 cryoprecipitates from patients with hepatitis, chronic active hepatitis, essential mixed cryoglobulinemia, and inflammatory bowel diseases were analyzed and screened for the presence of FN. Most cryoproteins of patients with essential mixed cryoglobulinemia and inflammatory bowel diseases were of the mixed IgM-IgG type and all contained FN. In contrast, most cryoproteins of patients with hepatitis were composed of polyclonal IgM and were devoid of FN. It is possible that FN characterizes and facilitates the formation of mixed cryoglobulins. However, its presence does not seem to be an absolute requirement for cryoprecipitation.
纤连蛋白（FN）与纤维蛋白 - 纤维蛋白原复合物的冷沉淀有关。初步观察表明，它可能在冷球蛋白血症中也起作用。在本研究中，对32例来自患有肝炎、慢性活动性肝炎、原发性混合性冷球蛋白血症和炎症性肠病患者的冷沉淀物进行了分析，并筛查了FN的存在情况。原发性混合性冷球蛋白血症和炎症性肠病患者的大多数冷球蛋白是IgM - IgG混合型，且均含有FN。相比之下，肝炎患者的大多数冷球蛋白由多克隆IgM组成，且不含FN。FN可能是混合冷球蛋白的特征并促进其形成。然而，其存在似乎并非冷沉淀的绝对必要条件。
