Taylor R L, Burt D R
J Neurochem. 1982 Jun;38(6):1649-56. doi: 10.1111/j.1471-4159.1982.tb06646.x.
A survey of the regional distribution of binding of 1 nM 3Hthyrotropin-releasing hormone ([3H]MeTRH) to TRH receptors in the brains of eight mammalian species revealed major species differences in both the absolute and relative values of TRH receptor binding in different brain regions. Several brain regions exhibited binding equal to or exceeding that in the anterior pituitary gland of the same species, including the amygdala in the guinea pig and rat, the hypothalamus in the guinea pig, the nucleus accumbens in the rabbit, and all these and other regions in the cat and dog, for which pituitary binding was exceptionally low. Species could be divided into two groups according to which brain region appeared highest in binding: rabbits, sheep, and cattle had highest binding in the nucleus accumbens/septal area, whereas guinea pigs, rats, dogs, cats, and pigs had highest binding in the amygdala/temporal cortex area. The nucleus accumbens consistently exceeded the caudate-putamen in receptor binding. For most brain regions, rabbits, rodents, and sheep tended to be higher than carnivores, cattle, or pigs. Further regions that exhibited appreciable binding in most species included the olfactory bulb and tubercle, hippocampus, and various cortical and brain stem areas. In fact, essentially all brain regions appeared to have detectable levels of TRH receptors in at least some species, but no rat peripheral tissues have yet shown detectable receptor binding. The species differences appeared to reflect largely if not entirely differences in receptor density, although this was not tested in every species.
一项对1 nM 3H促甲状腺激素释放激素([3H]MeTRH)与8种哺乳动物脑内促甲状腺激素释放激素(TRH)受体结合的区域分布的调查显示，不同脑区TRH受体结合的绝对值和相对值在主要物种间存在差异。几个脑区的结合水平等于或超过同一物种垂体前叶的结合水平，包括豚鼠和大鼠的杏仁核、豚鼠的下丘脑、兔子的伏隔核，以及猫和狗的所有这些区域及其他区域，而它们垂体的结合水平异常低。根据结合水平最高的脑区，物种可分为两组：兔子、绵羊和牛在伏隔核/隔区的结合水平最高，而豚鼠、大鼠、狗、猫和猪在杏仁核/颞叶皮质区的结合水平最高。伏隔核的受体结合水平始终超过尾状核-壳核。对于大多数脑区，兔子、啮齿动物和绵羊的结合水平往往高于食肉动物、牛或猪。在大多数物种中显示出明显结合的其他区域包括嗅球和结节、海马体，以及各种皮质和脑干区域。事实上，基本上所有脑区在至少某些物种中似乎都有可检测到的TRH受体水平，但尚未在大鼠外周组织中检测到可检测到的受体结合。物种差异似乎在很大程度上(如果不是完全)反映了受体密度的差异，尽管并非对每个物种都进行了测试。
