Koch B, Sakly M, Lutz-Bucher B, Briaud B
J Physiol (Paris). 1981 Mar;77(8):923-33.
This report attempts to summarize the present state of knowledge concerning interaction of glucocorticoids with brain and pituitary receptors, in relation to induction of specific biological effects. It examines the properties of the receptors, emphasizing the fact that transcortin-like binding molecules are present on the cell membrane in the pituitary gland. Also, it considers the functional aspects of the mechanism of action of steroids, including control, occupancy and heterogeneity of binding sites, as well as correlation with regulation of ACTH release.
本报告试图总结关于糖皮质激素与脑和垂体受体相互作用的现有知识状态，及其与特定生物学效应诱导的关系。它研究了受体的特性，强调垂体细胞膜上存在类皮质素结合分子这一事实。此外，它还考虑了类固醇作用机制的功能方面，包括结合位点的控制、占据和异质性，以及与促肾上腺皮质激素（ACTH）释放调节的相关性。
