Manning P J, Frisk C S
Lab Anim Sci. 1981 Oct;31(5 Pt 2):574-7.
An epizootic of mousepox in two colonies of mice was described. Clinical signs, morbidity and mortality rates, and necropsy lesions were substantially influenced by husbandry practices, intercurrent diseases (Sendai pneumonia, mouse hepatitis virus), and total body x-irradiation. In one colony, 54 mice were necropsied; 19 mice had cutaneous or visceral lesions of mousepox although none had combined visceral and cutaneous lesions. In the other colony, 20 mice were necropsied, and 10 mice had cutaneous lesions; none had visceral lesions. Sera from 24 mice with the cutaneous form of the disease had no demonstrable HI antibody titer. Experimental mice injected with spleen/liver homogenates from infected colony mice developed typical visceral lesions with numerous poxvirus profiles on electron micrographs and positive HI titers. Mice immunized with vaccinia virus were not susceptible to the disease.
描述了两个小鼠群体中发生的鼠痘流行情况。临床症状、发病率和死亡率以及尸检病变受到饲养管理方式、并发疾病（仙台肺炎、小鼠肝炎病毒）和全身X射线照射的显著影响。在一个群体中，对54只小鼠进行了尸检；19只小鼠有鼠痘的皮肤或内脏病变，尽管没有一只同时有内脏和皮肤病变。在另一个群体中，对20只小鼠进行了尸检，10只小鼠有皮肤病变；没有一只小鼠有内脏病变。24只患皮肤型疾病的小鼠血清中未检测到可证明的血凝抑制（HI）抗体效价。注射来自感染群体小鼠的脾/肝匀浆的实验小鼠出现典型的内脏病变，电子显微镜下有大量痘病毒形态，且血凝抑制效价呈阳性。用痘苗病毒免疫的小鼠对该病不敏感。
