Port C D, Van Pelt L F, Williams R M
Lab Anim Sci. 1982 Feb;32(1):74-7.
A 225-day-old male fourth generation rat from a developing recombinant inbred line (Lewis x Brown Norway) had a bilaterally symmetrical enlargement of the scrotum. Palpation indicated the presence of a firm lobulated mass extending from the tip of the scrotum to the abdominal wall. Bilateral nodular masses totally occupied the scrotal sacs, surrounded the testicles, and extended along the spermatic cords into the abdominal cavity. Tumor nodules also were present in the intestinal mesentery, omentum, mesenteric lymph nodes, pancreas, and lung. Histologically, the neoplasm presented a spectrum of characteristics varying from that of a granuloma with giant cells to a diffuse proliferation of spindle-shaped mononuclear cells.
一只来自发育中的重组近交系（Lewis×Brown Norway）的225日龄雄性第四代大鼠阴囊出现双侧对称性肿大。触诊发现有一个坚实的分叶状肿块，从阴囊尖端延伸至腹壁。双侧结节状肿块完全占据阴囊囊，包围睾丸，并沿精索延伸至腹腔。肿瘤结节也存在于肠系膜、网膜、肠系膜淋巴结、胰腺和肺中。组织学上，肿瘤呈现出一系列特征，从含有巨细胞的肉芽肿到梭形单核细胞的弥漫性增殖不等。
