Kaspareit-Rittinghausen J, Deerberg F
Department of Pathology, Central Institute for Laboratory Animal Breeding, Hannover, FRG.
J Comp Pathol. 1988 Oct;99(3):299-307. doi: 10.1016/0021-9975(88)90050-3.
Histopathological findings and anatomical distribution of histiocytic sarcomas found in an uncommonly high frequency (50 of 399 rats) in the BD II/Han inbred strain are reported. The incidence of the tumours in male rats was significantly higher than in females. This was in part attributed to a shorter life expectancy of female rats. Tumours identified were composed of histiocytic cells. Other histological features included Langhans-type giant cells, palisading of histiocytes around necrosis and granuloma-like arrangements of cells. The highest incidence of histiocytic sarcomas was found in the subcutis. Other organs frequently involved were lungs and liver. The histopathological findings in BD II/Han rats are compared with previously reported histiocytic sarcomas in other strains of rat.
据报道，在BD II/Han近交系大鼠中，组织细胞肉瘤出现的频率异常高（399只大鼠中有50只），本文报告了其组织病理学发现及解剖分布情况。雄性大鼠的肿瘤发生率显著高于雌性大鼠。这部分归因于雌性大鼠的预期寿命较短。所鉴定出的肿瘤由组织细胞构成。其他组织学特征包括朗汉斯型巨细胞、坏死周围组织细胞的栅栏状排列以及细胞的肉芽肿样排列。组织细胞肉瘤的最高发生率见于皮下组织。其他常受累的器官是肺和肝。将BD II/Han大鼠的组织病理学发现与先前报道的其他大鼠品系中的组织细胞肉瘤进行了比较。
