Chretien J H, Garagusi V F
Med Clin North Am. 1982 May;66(3):675-87. doi: 10.1016/s0025-7125(16)31415-8.
Fungal infections of the gastrointestinal tract have risen to higher levels of prevalence in the past decade. Major factors accounting for this increase are social changes, such as the increased ease and frequency of travel, which exposes the individual to environmental conditions that may result in fungal infection; increasing use of antibiotic and hormonal medications by otherwise healthy persons; and improved therapy for other diseases, such as polychemotherapy of cancer with its immunosuppressive effects. Both noninvasive and invasive fungal disease of the intestinal tract in otherwise healthy individuals can be successfully treated. The invasive fungal infections in patients with severe prior underlying disease are often first diagnosed postmortem, but improvement in serologic techniques now offers a possibility of earlier diagnosis and therapeutic intervention.
在过去十年中，胃肠道真菌感染的患病率已升至更高水平。导致这种增加的主要因素是社会变革，例如旅行的便利性和频率增加，这使个体暴露于可能导致真菌感染的环境条件下；原本健康的人对抗生素和激素类药物的使用增加；以及其他疾病治疗方法的改进，如具有免疫抑制作用的癌症多药化疗。原本健康个体的肠道非侵袭性和侵袭性真菌病都可以得到成功治疗。患有严重基础疾病的患者中的侵袭性真菌感染通常在死后才首次被诊断出来，但血清学技术的改进现在为早期诊断和治疗干预提供了可能性。
