Zetler G
Neurosci Lett. 1982 Mar 5;28(3):287-90. doi: 10.1016/0304-3940(82)90072-6.
Cholecystokinin octapeptide (CCK-8), caerulein and diazepam inhibited exploratory rearing activity and harman-induced convulsions in mice. Pretreatment with the selective benzodiazepine receptor antagonist Ro 15-1788, reduced or abolished the sedative and anticonvulsive effects of diazepam, but left the same effects of both peptides unaffected. The peptide-induced ptosis was even increased by Ro 15-1788. The results suggest that the CCK-like peptides do not directly interact with the benzodiazepine receptor.
胆囊收缩素八肽（CCK - 8）、蛙皮素和地西泮可抑制小鼠的探究性竖毛活动及哈尔满诱导的惊厥。用选择性苯二氮䓬受体拮抗剂Ro 15 - 1788预处理，可降低或消除地西泮的镇静和抗惊厥作用，但两种肽的相同作用不受影响。Ro 15 - 1788甚至会增强肽诱导的眼睑下垂。结果表明，CCK样肽不直接与苯二氮䓬受体相互作用。
