Christensen K K
Obstet Gynecol. 1982 Apr;59(4):499-508.
During a 15-month period, all 34 infants delivered at the department of obstetrics and gynecology at University Hospital in Lund, Sweden, who died perinatally or neonatally were included in a prospective study of causes of death. Autopsies--including extensive culturing of specimens for bacteria, chlamydia, fungi, mycoplasmas, and viruses--were performed for all infants. Maternal sera obtained during pregnancy and after delivery were examined regarding titers against a number of microorganisms. During the study period, the perinatal mortality rate was 0.60% and the neonatal mortality rate 0.56%. It was found that 37% of the deaths were caused by lethal malformations, 17% by idiopathic respiratory distress syndrome, and 9% by ablatio placentae. However, no less than 21% occurred as a direct consequence of infections, including 2 deaths caused by group B streptococci, 2 by Coxsackie B virus, and 3 deaths each by Hemophilus influenzae, Pseudomonas pyocyanea, and Candida albicans. A 6-month study of late abortions revealed another case of intrauterine group B streptococcal infection. The study has demonstrated that autopsy, including microbial examination, is recommended in all cases of perinatal and neonatal deaths.
在15个月的时间里，瑞典隆德大学医院妇产科分娩的所有34例围产期或新生儿期死亡的婴儿都被纳入一项关于死亡原因的前瞻性研究。对所有婴儿进行了尸检，包括对标本进行细菌、衣原体、真菌、支原体和病毒的广泛培养。检测了孕期和产后采集的母体血清中针对多种微生物的抗体滴度。在研究期间，围产期死亡率为0.60%，新生儿死亡率为0.56%。结果发现，37%的死亡是由致命畸形引起的，17%是由特发性呼吸窘迫综合征引起的，9%是由胎盘早剥引起的。然而，多达21%的死亡是感染的直接后果，包括2例由B族链球菌引起的死亡、2例由柯萨奇B病毒引起的死亡，以及各3例由流感嗜血杆菌、铜绿假单胞菌和白色念珠菌引起的死亡。一项关于晚期流产的6个月研究发现了另一例宫内B族链球菌感染病例。该研究表明，对于所有围产期和新生儿死亡病例，建议进行包括微生物检查在内的尸检。
