Piraino F F, Sedmak G, Raab K
Public Health Rep. 1982 Jul-Aug;97(4):346-53.
Echovirus serotype 11 (ECHO-11) was implicated in three neonatal deaths during an enterovirus outbreak from July through October 1979 in Milwaukee. The deaths followed congenital infections acquired in the community during late pregnancy. Two of the three ECHO-11 and one Coxsackie B4 deaths of infants occurred after cesarean section deliveries. Of 225 confirmed echovirus infections, 30 to 45 percent occurred in infants under 60 days old, 54 to 67 percent in the first year of life, and 13 to 25 percent in the over-10 age groups. In 13 cases with onset of symptoms in the first week of life. 8 (including the 4 fatalities) were acquired congenitally; 6 of the 8 were associated with ECHO-11, 2 with ECHO-7, and 1 with Coxsackie B4. ECHO-7 and 30 other predominant strains were isolated during the outbreak, but none was associated with mortality or severe disease in neonates. At a Milwaukee hospital, a temporal association was observed between echovirus infection, particularly ECHO-11, and increased numbers of stillbirths.
1979年7月至10月在密尔沃基发生肠道病毒疫情期间，11型艾柯病毒（ECHO - 11）与三例新生儿死亡有关。这些死亡是由于在妊娠晚期在社区获得的先天性感染所致。三例ECHO - 11感染婴儿中的两例以及一例柯萨奇B4感染婴儿的死亡发生在剖宫产分娩后。在225例确诊的艾柯病毒感染病例中，30%至45%发生在60日龄以下的婴儿，54%至67%发生在生命的第一年，13%至25%发生在10岁以上的年龄组。在13例出生后第一周出现症状的病例中，8例（包括4例死亡病例）是先天性感染；8例中的6例与ECHO - 11有关，2例与ECHO - 7有关，1例与柯萨奇B4有关。在疫情期间分离出了ECHO - 7和其他30种主要毒株，但没有一种与新生儿的死亡或严重疾病有关。在密尔沃基的一家医院，观察到艾柯病毒感染，特别是ECHO - 11感染与死产数量增加之间存在时间关联。
