Elgebaly S, Kunkel S, Lovett E J, Varani J
Oncology. 1982;39(3):163-6. doi: 10.1159/000225629.
The levels of 3',5'-cyclic adenosine monophosphate (cAMP) were measured in a high malignant and a low malignant clone of murine fibrosarcoma cells isolated from a common parent in a normal mouse fibroblasts at various stages of growth. There was an inverse correlation between the degree of malignant potential and the cAMP levels. The normal fibroblasts had the highest cAMP at all time periods measured. The high malignant cells had the lowest levels and the low malignant cells were intermediary. The degree of susceptibility of each population to the growth inhibiting effects of dibutyryl cAMP, a cAMP analogue, was also measured. There was a direct correlation between degree of malignant potential and susceptibility to growth inhibition. These findings strongly support our belief that the low malignant cells represent a state of malignancy that is intermediary between the high malignant cells and the normal fibroblasts. cAMP differences may contribute to this.
在正常小鼠成纤维细胞的不同生长阶段，从同一亲本分离出的高恶性和低恶性小鼠纤维肉瘤细胞克隆中，测量了3',5'-环磷酸腺苷（cAMP）的水平。恶性潜能程度与cAMP水平呈负相关。在所有测量时间段，正常成纤维细胞的cAMP水平最高。高恶性细胞的水平最低，低恶性细胞处于中间水平。还测量了每个细胞群体对cAMP类似物二丁酰cAMP生长抑制作用的敏感程度。恶性潜能程度与生长抑制敏感性呈正相关。这些发现有力地支持了我们的观点，即低恶性细胞代表了一种介于高恶性细胞和正常成纤维细胞之间的恶性状态。cAMP差异可能对此有影响。
