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胰岛素和生长因子对细胞内蛋白质降解的调节。

Regulation of intracellular protein degradation by insulin and growth factors.

作者信息

Ballard F J, Nield M K, Francis G L, Knowles S E

出版信息

Acta Biol Med Ger. 1981;40(10-11):1293-300.

PMID:6282020
Abstract

Protein breakdown in many cell lines is inhibited by growth factors. The response is specific, rapid and additive only at suboptimal concentrations. Transformed cells are typically more sensitive to growth factors than nontransformed cells while the effectiveness of growth factors in human fibroblasts is diminished with senescence. Bovine colostrum has been shown to be an extremely rich source of growth factors as compared to serum.

摘要

许多细胞系中的蛋白质分解受到生长因子的抑制。这种反应具有特异性、快速性,且仅在次优浓度下具有累加性。与未转化细胞相比,转化细胞通常对生长因子更为敏感,而生长因子在人成纤维细胞中的有效性会随着衰老而降低。与血清相比,牛初乳已被证明是生长因子的极其丰富的来源。

相似文献

1
Regulation of intracellular protein degradation by insulin and growth factors.胰岛素和生长因子对细胞内蛋白质降解的调节。
Acta Biol Med Ger. 1981;40(10-11):1293-300.
2
[The effect of growth factors on cell cultures].[生长因子对细胞培养的影响]
Acta Histochem Suppl. 1983;27:73-86.
3
The relationship between the insulin content and inhibitory effects of bovine colostrum on protein breakdown in cultured cells.
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Regulation of casein kinase II by growth factors: a reevaluation.生长因子对酪蛋白激酶II的调控:重新评估
Cell Mol Biol Res. 1994;40(5-6):373-81.
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Effect of rous sarcoma virus transformation of rat-1 fibroblasts upon their growth factor and anchorage requirements in serum-free medium.劳氏肉瘤病毒对大鼠-1成纤维细胞的转化对其在无血清培养基中生长因子及贴壁需求的影响。
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Insulin inhibition of protein degradation in cell monolayers.胰岛素对细胞单层中蛋白质降解的抑制作用。
J Cell Physiol. 1980 Nov;105(2):335-46. doi: 10.1002/jcp.1041050216.
7
Synergistic effects of epidermal growth factor and thrombin on the growth stimulation of diploid Chinese hamster fibroblasts.表皮生长因子和凝血酶对二倍体中国仓鼠成纤维细胞生长刺激的协同作用。
J Cell Physiol. 1980 Oct;105(1):25-32. doi: 10.1002/jcp.1041050105.
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Control of cytolysis of BALB/c-3T3 cells by platelet-derived growth factor: a model system for analyzing cell death.血小板衍生生长因子对BALB/c-3T3细胞细胞溶解的控制:一种分析细胞死亡的模型系统
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Regulation of the Balb/c-3T3 cell cycle-effects of growth factors.Balb/c - 3T3细胞周期的调控——生长因子的作用
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10
Failure of hydrocortisone or growth factors to influence the senescence of fibroblasts in a new culture system for assessing replicative lifespan.在一种用于评估复制寿命的新培养系统中,氢化可的松或生长因子未能影响成纤维细胞的衰老。
J Cell Physiol. 1981 Oct;109(1):171-9. doi: 10.1002/jcp.1041090119.

引用本文的文献

1
Distinct proteolytic mechanisms in serum-sufficient and serum-restricted fibroblasts. Transformed 3T3 cells fail to regulate proteolysis in relation to culture density only during serum-sufficiency.血清充足和血清受限的成纤维细胞中不同的蛋白水解机制。仅在血清充足时,转化的3T3细胞在与培养密度相关的情况下无法调节蛋白水解。
Biochem J. 1984 Jul 1;221(1):53-60. doi: 10.1042/bj2210053.
2
Inhibition of protein breakdown by epidermal growth factor in IMR90 human fibroblasts and other mammalian cell lines.表皮生长因子对IMR90人成纤维细胞及其他哺乳动物细胞系中蛋白质分解的抑制作用。
Biochem J. 1983 Jan 15;210(1):251-8. doi: 10.1042/bj2100251.
3
Binding properties and biological potencies of insulin-like growth factors in L6 myoblasts.
L6成肌细胞中胰岛素样生长因子的结合特性与生物学活性
Biochem J. 1986 Jan 1;233(1):223-30. doi: 10.1042/bj2330223.