Vernon S E
Acta Cytol. 1982 Mar-Apr;26(2):237-42.
Herpesvirus infections of the lower respiratory tract have most commonly been reported in patients with severe burns, immunosuppression or malignancies. Two patients without any of these underlying conditions developed severe herpetic tracheobronchitis, diagnosed by cytologic examination and confirmed by serologic studies. Serial examination of sputum, bronchial brushings and bronchial washings permitted observation of the evolution and progression of cellular changes found in herpesvirus infection of the lower respiratory tract. both patients recovered without specific antiviral therapy, but both developed superinfection with gram-negative organisms, requiring intensive antibiotic therapy. The distinctive features of herpesvirus infection in the tracheobronchial tree are similar to those recognized elsewhere in the body. Early findings include a variety of nonspecific changes in nuclear chromatin configurations; multinucleated cells may be common but do not often contain the central intranuclear inclusion bodies seen in later stages. These distinctive central intranuclear inclusions disappear in a few days, leaving only reparative changes in the surface epithelium. Herpesviruses are increasingly being reported in the literature as an etiologic agent of acute tracheobronchitis in otherwise healthy individuals.
下呼吸道疱疹病毒感染最常见于严重烧伤、免疫抑制或恶性肿瘤患者。两名无上述任何基础疾病的患者发生了严重的疱疹性气管支气管炎，通过细胞学检查确诊并经血清学研究证实。对痰液、支气管刷检物和支气管冲洗液进行系列检查，得以观察到下呼吸道疱疹病毒感染中细胞变化的演变和进展。两名患者均未接受特异性抗病毒治疗而康复，但均发生了革兰氏阴性菌的二重感染，需要强化抗生素治疗。气管支气管树中疱疹病毒感染的独特特征与身体其他部位所见相似。早期表现包括核染色质构型的多种非特异性变化；多核细胞可能常见，但通常不含后期可见的中央核内包涵体。这些独特的中央核内包涵体在数天内消失，仅在表面上皮留下修复性改变。文献中越来越多地报道疱疹病毒是健康个体急性气管支气管炎的病原体。
