Jackson R T
Ann Otol Rhinol Laryngol. 1982 Mar-Apr;91(2 Pt 1):216-9. doi: 10.1177/000348948209100220.
Noradrenergic synapses in the heart and several blood vessels have been shown to possess prejunctional receptors that modulate the release of norepinephrine from the synapse. The present experiment attempted to find evidence for presynaptic receptors for acetylcholine that modulated norepinephrine release. From the evidence obtained, it appears that the acetylcholine released from nasal parasympathetic fibers does not directly affect the smooth muscle of nasal blood vessels. Acetylcholine does, however, appear to inhibit the release of norepinephrine from nasal sympathetic nerve terminals. It appears that any nasal vasodilation produced by nasal parasympathetic fibers is caused by acetylcholine acting on an inhibitory, presynaptic, muscarinic receptor on the sympathetic nerve terminals. Acetylcholine would exert its control over nasal vessels by regulating the degree of sympathetic neurotransmitter release.
已证实，心脏和一些血管中的去甲肾上腺素能突触拥有调节突触中去甲肾上腺素释放的突触前受体。本实验试图寻找调节去甲肾上腺素释放的乙酰胆碱突触前受体的证据。从获得的证据来看，鼻副交感神经纤维释放的乙酰胆碱似乎不会直接影响鼻血管的平滑肌。然而，乙酰胆碱似乎会抑制鼻交感神经末梢去甲肾上腺素的释放。鼻副交感神经纤维产生的任何鼻血管舒张似乎是由乙酰胆碱作用于交感神经末梢上的抑制性突触前毒蕈碱受体引起的。乙酰胆碱将通过调节交感神经递质的释放程度来控制鼻血管。
