头孢噻肟在儿科患者中的临床药理学
Clinical pharmacology of cefotaxime in pediatric patients.
作者信息
Kafetzis D A, Brater D C, Kanarios J, Sinaniotis C A, Papadatos C J
出版信息
Antimicrob Agents Chemother. 1981 Oct;20(4):487-90. doi: 10.1128/AAC.20.4.487.
Abstract
Cefotaxime is a new cephalosporin with a spectrum of activity which may make it appropriate for use in pediatric patients. In 33 infants and children, administration of cefotaxime resulted in cure or improvement in 97% of patients, with eradication of 94% of isolated pathogens. Toxicity was minimal. The disposition of cefotaxime in this age group was similar to that reported for adults, with an elimination half-life of approximately 1.5 h, a volume of distribution of 1 liter/kg, a total serum clearance of 10 ml/min per kg, and a renal clearance of 6 ml/min per kg.
摘要
头孢噻肟是一种新型头孢菌素，其抗菌谱可能使其适用于儿科患者。在33例婴儿和儿童中，使用头孢噻肟治疗后，97%的患者治愈或病情改善，94%的分离病原菌被清除。毒性极小。该年龄组中头孢噻肟的处置情况与成人报道的相似，消除半衰期约为1.5小时，分布容积为1升/千克，总血清清除率为每千克每分钟10毫升，肾清除率为每千克每分钟6毫升。
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本文引用的文献
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Metabolism of cefotaxime in animals and man.头孢噻肟在动物和人体内的代谢。
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Cefotaxime in the treatment of severe paediatric infections.头孢噻肟治疗小儿严重感染
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