Ireland C M, Cheung H T, Ryan A J, Holder G M
Chem Biol Interact. 1982 Jul 1;40(3):305-18. doi: 10.1016/0009-2797(82)90153-3.
The metabolism of the weak carcinogen 7-methylbenz[c]acridine (7MBAC) was examined in rat liver microsomes from 3-methylcholanthrene(MC)-induced animals by the use of mixed 14C- and 2H-labelled substrate. The three metabolites identified by spectroscopic and chromatographic examination were 7-OHMBAC and two dihydrodiols. The dihydrodiols were assigned structures consisted with attack on the 8,9- and 5,6- or K-region of the aromatic system.
利用混合的14C和2H标记底物，在3-甲基胆蒽（MC）诱导的大鼠肝脏微粒体中研究了弱致癌物7-甲基苯并[c]吖啶（7MBAC）的代谢情况。通过光谱和色谱检测鉴定出的三种代谢产物为7-羟基-7-甲基苯并[c]吖啶（7-OHMBAC）和两种二氢二醇。这些二氢二醇的结构被确定为是对芳香体系的8,9-位和5,6-位或K区进行攻击的结果。
