von Eyben F E, Arwidi A, Hellekant C, Jonsson K, Lindahl S A, Mattsson W, Tennvall L
Cancer Chemother Pharmacol. 1982;7(2-3):195-7. doi: 10.1007/BF00254547.
Twelve patients with small-cell anaplastic carcinoma of the lung were treated with vincristine 1 mg/m2 i.v. day 1, adriamycin 50 mg/M2 i.v. day 1, cyclophosphamide 1,000 mg/m2 i.v. day 1, and etoposide 80 mg/m2 i.v. day 2, 4, 6 given on an outpatient basis and repeated at 3-week intervals. As consolidation therapy seven patients received two courses of BCNU median 29 mg/m2 (range 24-73 mg/m2) short term intraarterial infusion in the bronchial artery with 2 to 3-weeks intervals. One patient with limited disease had no evidence of disease for 13+ months and one patient complete remission for 3+ months. Four of ten patients with extensive disease had complete remission for median 5 months (range 2+ to 5+ months) and four patients had partial remission for median 5 months (range 4 to 5+ months). Despite side effects the chemotherapy was well tolerated by the patients. The results correspond to those obtained with other effective regimens in small-cell anaplastic carcinoma of the lung.
12例肺小细胞间变性癌患者接受了如下治疗：长春新碱1毫克/平方米，静脉注射，第1天；阿霉素50毫克/平方米，静脉注射，第1天；环磷酰胺1000毫克/平方米，静脉注射，第1天；依托泊苷80毫克/平方米，静脉注射，第2、4、6天，在门诊进行治疗，并每3周重复一次。作为巩固治疗，7例患者接受了两疗程的卡氮芥，剂量中位数为29毫克/平方米（范围24 - 73毫克/平方米），通过支气管动脉进行短期动脉内输注，间隔2至3周。1例局限性疾病患者在13个多月内无疾病证据，1例患者完全缓解3个多月。10例广泛性疾病患者中有4例完全缓解，中位数为5个月（范围2个多月至5个多月），4例患者部分缓解，中位数为5个月（范围4至5个多月）。尽管有副作用，但患者对化疗耐受性良好。这些结果与在肺小细胞间变性癌中使用其他有效方案所获得的结果一致。
