Peterson J W
Circ Res. 1982 Jun;50(6):848-55. doi: 10.1161/01.res.50.6.848.
In a previous study (Peterson and Glück, 1982), activation of hog carotid artery with high-K+ medium caused no increase in aerobic glycolysis (lactic acid production). In contrast, histamine alone is found to stimulate aerobic glycolysis in a tension-dependent fashion (GLück and Paul, 1977). In this study, the addition of histamine to the already K+-depolarized hog carotid artery induced additional contraction, elevated tissue cyclic adenosine 3',5'-monophosphate [cAMP] levels, coupled the rate of aerobic glycolysis to external [Ca++] and isometric tension, and caused suprabasal energy utilization to exceed that required to support the contraction alone by approximately 25%. Increased cytoplasmic free-[Ca++] per se does not stimulate aerobic glycolysis. In the presence of histamine, however, aerobic glycolysis is Ca++-sensitive. Whereas a cycle of Ca++ depletion and restoration has only a small effect on basal metabolic rates in arteries activated with high-K+ alone, the same procedure with arteries stimulated by high-K+ with added histamine causes a dramatic shift in basal metabolic rates toward higher levels of glycolysis.
在之前的一项研究中（彼得森和格吕克，1982年），用高钾培养基激活猪颈动脉并未导致有氧糖酵解（乳酸生成）增加。相比之下，单独使用组胺会以张力依赖的方式刺激有氧糖酵解（格吕克和保罗，1977年）。在本研究中，向已经被钾离子去极化的猪颈动脉中添加组胺会引发额外的收缩，提高组织环磷酸腺苷（cAMP）水平，使有氧糖酵解速率与细胞外钙离子浓度和等长张力相关联，并导致基础能量利用率超过仅维持收缩所需能量约25%。细胞质中游离钙离子浓度升高本身并不会刺激有氧糖酵解。然而，在有组胺存在的情况下，有氧糖酵解对钙离子敏感。虽然钙离子耗竭和恢复的循环对仅用高钾激活的动脉基础代谢率影响较小，但对添加组胺并用高钾刺激的动脉进行相同操作会使基础代谢率显著转向更高水平的糖酵解。
