Kuhar M J
J Clin Psychiatry. 1982 Jun;43(6 Pt 2):17-9.
Clonidine acts at specific receptor sites in the brain. These sites, i.e. adrenergic receptors, can be localized in the brain at the light-microscopic level by utilizing autoradiographic techniques. Autoradiographic studies revealed a striking differential distribution throughout the brain. These results provide an anatomical basis for understanding the actions of clonidine in the CNS. For example, the finding of high densities of alpha-2-receptors in the nucleus tractus solitarius and in the dorsal motor nucleus of the vagus is very likely related to its antihypertensive action. Also, the striking codistribution of alpha-2 receptors with opiate receptors in some areas could provide an explanation for the observation that alpha-2 drugs block opiate withdrawal.
可乐定作用于大脑中的特定受体部位。这些部位，即肾上腺素能受体，可通过放射自显影技术在光学显微镜水平上定位在大脑中。放射自显影研究揭示了其在整个大脑中显著的差异分布。这些结果为理解可乐定在中枢神经系统中的作用提供了解剖学基础。例如，在孤束核和迷走神经背运动核中发现高密度的α₂受体很可能与其抗高血压作用有关。此外，在某些区域α₂受体与阿片受体的显著共分布可以解释α₂药物阻断阿片戒断的现象。
