Ferguson I T, Murphy R P, Lascelles R G
J Neurol Neurosurg Psychiatry. 1982 Mar;45(3):217-22. doi: 10.1136/jnnp.45.3.217.
This retrospective study over the decade 1969-1978 examines the precipitating factors and outcome in thirty-one patients with myasthenia gravis who developed ventilatory failure. An unusual example of chronic alveolar hypoventilation is discussed in detail. The most favourable outcome occurred in younger patients with a hyperplastic thymus, in contrast to a poorer outlook for older patients with an atrophic gland. Eleven patients died during the period of follow up: three deaths were unrelated to myasthenia but the remaining eight were attributed directly or indirectly to it. The mortality of 36% represents a marked improvement on a 70% mortality in a similar group of patients, reported from this hospital for the years 1960-1968.
这项针对1969年至1978年这十年间的回顾性研究，调查了31例发生呼吸衰竭的重症肌无力患者的诱发因素及预后情况。文中详细讨论了一个慢性肺泡通气不足的特殊病例。增生性胸腺的年轻患者预后最佳，而胸腺萎缩的老年患者预后较差。在随访期间有11例患者死亡：3例死亡与重症肌无力无关，但其余8例直接或间接归因于该病。36%的死亡率与本院报告的1960年至1968年类似患者群体70%的死亡率相比有显著改善。
