Hoffman P L, Urwyler S, Tabakoff B
J Pharmacol Exp Ther. 1982 Jul;222(1):182-9.
The dose-response curve for morphine-induced stimulation of striatal dopamine metabolism was shifted to the right in mice which had been withdrawn for 24 hours after chronic consumption of an ethanol-containing liquid diet. The apparent ED50 for morphine was increased by 33% in ethanol-treated mice. Concomitant with the shift in the dose-response curve, the affinity for dihydromorphine of the high-affinity caudate morphine receptor was decreased in ethanol-treated mice. The change in receptor properties after ethanol treatment included a decreased sensitivity of the receptor to the effects of sodium ion on morphine binding. The results suggest: 1) that the effect of morphine on dopamine metabolism in the mouse striatum is, at least in part, mediated by receptors that exhibit a high affinity for dihydromorphine: and 2) that ethanol treatment and withdrawal may induce specific changes in these particular opiate receptors.
在长期食用含乙醇液体饲料后戒断24小时的小鼠中，吗啡诱导纹状体多巴胺代谢的剂量-反应曲线向右移动。在乙醇处理的小鼠中，吗啡的表观半数有效剂量（ED50）增加了33%。伴随剂量-反应曲线的移动，乙醇处理的小鼠中高亲和力尾状核吗啡受体对二氢吗啡的亲和力降低。乙醇处理后受体特性的变化包括受体对钠离子影响吗啡结合的敏感性降低。结果表明：1）吗啡对小鼠纹状体多巴胺代谢的作用至少部分是由对二氢吗啡具有高亲和力的受体介导的；2）乙醇处理和戒断可能会在这些特定的阿片受体中诱导特定变化。
