Brown D W, Collins W M, Ward P H, Briles W E
Poult Sci. 1982 Mar;61(3):409-13. doi: 10.3382/ps.0610409.
Relative responses to Rous sarcoma virus (RSV)-induced tumors were studied in UNH 105 chickens, a noninbred line of New Hampshires. A total of 799 chickens blood typed for B alloantigens were classified into six genotypes: B23/B23, B24/B24, B26/B26, B23/B24, B23/B26, and B24/B26. Chickens were inoculated with subgroup A Rous sarcoma virus in the left wingweb at 6 weeks of age. The in vivo response was evaluated and given a tumor profile index (TPI) based on the change in tumor size over a 10-week period postinoculation. The TPI's ranged from 1 (regressor) to 3 (progressor). The mean TPI of B23/B26 hosts (1.7) was significantly smaller than that of all other genotypes studied. The mean TPI's of the homozygous genotypes B23/B23, B26/B26, and B24/B24, were 2.0, 2.3, and 2.9, respectively, and differed significantly in all comparisons. These results suggest complementation of haplotypes influencing the anti-Rous sarcoma response.
在新罕布什尔非近交系的UNH 105鸡中研究了对劳氏肉瘤病毒（RSV）诱导肿瘤的相对反应。总共799只进行了B同种异体抗原血型鉴定的鸡被分为六种基因型：B23/B23、B24/B24、B26/B26、B23/B24、B23/B26和B24/B26。在6周龄时，给鸡的左翼接种A亚群劳氏肉瘤病毒。评估体内反应，并根据接种后10周内肿瘤大小的变化给出肿瘤概况指数（TPI）。TPI范围从1（消退型）到3（进展型）。B23/B26宿主的平均TPI（1.7）显著小于所研究的所有其他基因型。纯合基因型B23/B23、B26/B26和B24/B24的平均TPI分别为2.0、2.3和2.9，在所有比较中均有显著差异。这些结果表明影响抗劳氏肉瘤反应的单倍型存在互补作用。
