病毒src基因产物与哺乳动物环磷酸腺苷（cAMP）依赖性蛋白激酶的催化链相关。
Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.
作者信息
Barker W C, Dayhoff M O
出版信息
Proc Natl Acad Sci U S A. 1982 May;79(9):2836-9. doi: 10.1073/pnas.79.9.2836.
Abstract
The transforming protein sequences translated from the Rous avian and Moloney murine sarcoma virus src genes are shown to be related to the catalytic chain of bovine cAMP-dependent protein kinase (ATP:protein phosphotransferase, EC 2.7.1.37). The avian transforming protein, also a protein kinase, shows greatest homology with the bovine protein kinase in the carboxyl-terminal half, where the protein kinase activity is localized. Moreover, lysine occurs in the inferred transforming protein sequences at the position homologous with the proposed ATP-binding lysine of the bovine protein kinase. This relationship is consistent with the hypothesis that the src genes originated in the host genomes, in which they are members of a superfamily of distantly related protein kinases that are normal constituents of mammalian cells. In the host, these sequences are much more highly conserved than in the viruses.
摘要
从劳氏禽肉瘤病毒和莫洛尼鼠肉瘤病毒src基因翻译而来的转化蛋白序列，被证明与牛cAMP依赖性蛋白激酶（ATP：蛋白质磷酸转移酶，EC 2.7.1.37）的催化链相关。禽转化蛋白也是一种蛋白激酶，在羧基末端的一半区域与牛蛋白激酶具有最大的同源性，而蛋白激酶活性就定位于该区域。此外，在推断的转化蛋白序列中，赖氨酸出现在与牛蛋白激酶假定的ATP结合赖氨酸同源的位置。这种关系与src基因起源于宿主基因组的假说一致，在宿主基因组中，它们是哺乳动物细胞正常组成部分的远亲蛋白激酶超家族的成员。在宿主中，这些序列比在病毒中保守得多。
相似文献
1
Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.病毒src基因产物与哺乳动物环磷酸腺苷（cAMP）依赖性蛋白激酶的催化链相关。
Proc Natl Acad Sci U S A. 1982 May;79(9):2836-9. doi: 10.1073/pnas.79.9.2836.
2
The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo.槲皮素对劳氏肉瘤病毒转化基因产物在体外和体内磷酸化活性的影响。
Eur J Biochem. 1983 Oct 3;135(3):583-9. doi: 10.1111/j.1432-1033.1983.tb07692.x.
3
Functional studies on the Rous sarcoma virus transforming gene product.劳氏肉瘤病毒转化基因产物的功能研究
Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984;17:457-8.
4
Tyrosyl and cyclic AMP-dependent protein kinase activities in BHK cells that express viral pp60src.表达病毒pp60src的BHK细胞中的酪氨酰和环磷酸腺苷依赖性蛋白激酶活性。
Mol Cell Biol. 1984 May;4(5):973-7. doi: 10.1128/mcb.4.5.973-977.1984.
5
pp60v-src tyrosine kinase is expressed and active in sarcoma-free avian embryos microinjected with Rous sarcoma virus.pp60v-src酪氨酸激酶在注射了劳氏肉瘤病毒的无肉瘤禽胚胎中表达并具有活性。
Proc Natl Acad Sci U S A. 1988 Oct;85(20):7587-91. doi: 10.1073/pnas.85.20.7587.
6
Relationship of polypeptide products of the transforming gene of Rous sarcoma virus and the homologous gene of vertebrates.劳氏肉瘤病毒转化基因的多肽产物与脊椎动物同源基因的关系。
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2059-63. doi: 10.1073/pnas.77.4.2059.
7
Neither arginine nor histidine can carry out the function of lysine-295 in the ATP-binding site of p60src.精氨酸和组氨酸均无法在p60src的ATP结合位点发挥赖氨酸-295的功能。
Mol Cell Biol. 1986 Mar;6(3):751-7. doi: 10.1128/mcb.6.3.751-757.1986.
8
Structural and functional motifs of the Rous sarcoma virus src protein.劳氏肉瘤病毒src蛋白的结构和功能基序
Gene Amplif Anal. 1986;4:1-19.
9
Src Gene product from different strains of avian sarcoma virus: Kinetics and possible mechanism of heat inactivation of protein kinase activity from cells infected by transformation-defective, temperature-sensitive mutant and wild-type virus.来自不同禽肉瘤病毒株的Src基因产物：转化缺陷型、温度敏感型突变体和野生型病毒感染细胞中蛋白激酶活性热失活的动力学及可能机制。
Proc Natl Acad Sci U S A. 1979 Feb;76(2):967-71. doi: 10.1073/pnas.76.2.967.
10
Modification of carboxyl-terminal region is the cause of activation of the src gene in avian sarcoma virus S2.羧基末端区域的修饰是禽肉瘤病毒S2中src基因激活的原因。
Jpn J Cancer Res. 1986 Jul;77(7):611-4.
引用本文的文献
1
Role of the αC-β4 loop in protein kinase structure and dynamics.αC-β4环在蛋白激酶结构与动力学中的作用。
Elife. 2024 Dec 4;12:RP91980. doi: 10.7554/eLife.91980.
2
Improved selection of canonical proteins for reference proteomes.改进用于参考蛋白质组的标准蛋白质选择。
NAR Genom Bioinform. 2024 Jun 8;6(2):lqae066. doi: 10.1093/nargab/lqae066. eCollection 2024 Jun.
3
Protein Kinase Structure and Dynamics: Role of the αC-β4 Loop.蛋白激酶的结构与动力学：αC-β4环的作用
bioRxiv. 2023 Oct 16:2023.08.31.555822. doi: 10.1101/2023.08.31.555822.
4
Edmond Fischer's kinase legacy: History of the protein kinase inhibitor and protein kinase A.埃德蒙·菲舍尔的激酶遗产：蛋白激酶抑制剂和蛋白激酶 A 的历史。
IUBMB Life. 2023 Apr;75(4):311-323. doi: 10.1002/iub.2714. Epub 2023 Feb 28.
5
Evaluation of residue variability in a conformation-specific context and during evolutionary sequence reconstruction narrows drug resistance selection in Abl1 tyrosine kinase.评估构象特异性背景下和进化序列重建过程中的残差变异性，可缩小 Abl1 酪氨酸激酶的耐药性选择。
Protein Sci. 2022 Jul;31(7):e4354. doi: 10.1002/pro.4354.
6
Evolution of a dynamic molecular switch.动态分子开关的进化。
IUBMB Life. 2019 Jun;71(6):672-684. doi: 10.1002/iub.2059. Epub 2019 May 6.
7
Assembly of allosteric macromolecular switches: lessons from PKA.别构大分子开关的组装：PKA 的启示。
Nat Rev Mol Cell Biol. 2012 Oct;13(10):646-58. doi: 10.1038/nrm3432. Epub 2012 Sep 20.
8
Protein kinases: evolution of dynamic regulatory proteins.蛋白激酶：动态调节蛋白的进化。
Trends Biochem Sci. 2011 Feb;36(2):65-77. doi: 10.1016/j.tibs.2010.09.006. Epub 2010 Oct 23.
9
Analysis and organization of protein sequence data: a retrospective spanning four decades.蛋白质序列数据的分析与整理：跨越四十年的回顾
J Protein Chem. 1997 Jul;16(5):459-62. doi: 10.1023/a:1026305309829.
10
Importance of the A-helix of the catalytic subunit of cAMP-dependent protein kinase for stability and for orienting subdomains at the cleft interface.环磷酸腺苷依赖性蛋白激酶催化亚基的A螺旋对于稳定性以及在裂隙界面定向亚结构域的重要性。
Protein Sci. 1997 Mar;6(3):569-79. doi: 10.1002/pro.5560060306.
本文引用的文献
1
Homologous tyrosine phosphorylation sites in transformation-specific gene products of distinct avian sarcoma viruses.不同禽肉瘤病毒转化特异性基因产物中的同源酪氨酸磷酸化位点。
Nature. 1981 Jun 25;291(5817):675-7. doi: 10.1038/291675a0.
2
Viral and cellular src genes contribute to the structure of recovered avian sarcoma virus transforming protein.病毒和细胞的src基因对恢复的禽肉瘤病毒转化蛋白的结构有贡献。
Cell. 1981 Apr;24(1):155-64. doi: 10.1016/0092-8674(81)90511-0.
3
Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src).劳氏肉瘤病毒转化蛋白（pp60src）的结构域与功能域
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1624-8. doi: 10.1073/pnas.78.3.1624.
4
Complete amino acid sequence of the catalytic subunit of bovine cardiac muscle cyclic AMP-dependent protein kinase.牛心肌环磷酸腺苷依赖性蛋白激酶催化亚基的完整氨基酸序列。
Proc Natl Acad Sci U S A. 1981 Feb;78(2):848-51. doi: 10.1073/pnas.78.2.848.
5
Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus.小鼠肉瘤病毒转化基因的核苷酸序列与形成
Nature. 1981 Jan 22;289(5795):258-62. doi: 10.1038/289258a0.
6
Nucleotide sequence analysis of the transforming region and large terminal redundancies of Moloney murine sarcoma virus.莫洛尼氏鼠肉瘤病毒转化区及大末端冗余序列的核苷酸序列分析
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5234-8. doi: 10.1073/pnas.77.9.5234.
7
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product.禽肉瘤病毒癌基因（src）的核苷酸序列及基因产物的推测氨基酸序列。
Nature. 1980 Sep 18;287(5779):198-203. doi: 10.1038/287198a0.
8
Transforming gene product of Rous sarcoma virus phosphorylates tyrosine.劳氏肉瘤病毒的转化基因产物使酪氨酸磷酸化。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1311-5. doi: 10.1073/pnas.77.3.1311.
9
Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.在A-431细胞膜中鉴定磷酸酪氨酸为表皮生长因子激活的蛋白激酶的产物。
J Biol Chem. 1980 Sep 25;255(18):8363-5.
10
An improved method of testing for evolutionary homology.一种改进的进化同源性测试方法。
J Mol Biol. 1966 Mar;16(1):9-16. doi: 10.1016/s0022-2836(66)80258-9.
Zotero 插件