O'Brien C P, Stunkard A J, Ternes J W
Psychosom Med. 1982 May;44(2):215-23. doi: 10.1097/00006842-198205000-00007.
Studies in rodents suggest the possibility of an association between elevated endogenous opiate activity and overeating and obesity. One measure of elevated opiate activity is sensitivity to the opiate antagonist naloxone. Seven massively obese human subjects showed no subjective or physiological sensitivity to large intravenous doses of naloxone. This finding fails to support a relationship between elevated endorphin activity and human obesity.
对啮齿动物的研究表明，内源性阿片活性升高与暴饮暴食及肥胖之间可能存在关联。阿片活性升高的一个指标是对阿片拮抗剂纳洛酮的敏感性。七名极度肥胖的人类受试者对大剂量静脉注射纳洛酮未表现出主观或生理上的敏感性。这一发现不支持内啡肽活性升高与人类肥胖之间存在关联。
