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胸腺切除术治疗重症肌无力的评估(作者译)

[Evaluation of treatment of myasthenia with thymectomy (author's transl)].

作者信息

Rzepecki W, Lukasiewicz M, Emeryk B

出版信息

Sem Hop. 1982 Apr 22;58(16):985-7.

PMID:6283669
Abstract

The paper describes the effectiveness of treatment of myasthenia with thymectomy in 136 patients operated on, observed in hospital and 107 examined by questionnaire on late results after 10 years. Exclusive of myasthenia with thymoma, cures were obtained in 26.4%, marked improvement in 19.6%, moderate improvement in 21.4%, improved motor strength in 27.1%, and deterioration was observed in 3.8%. The assessment was based mainly on the amount of cholinergic drugs taken. Early mortality rate was 2,4%, and late mortality 1,9%. Relation of postoperative complications/respiratory and crisis of both kinds to mortality and intraoperative pleural injury also surgical approach and anatomic variants of the thymus were discussed. An influence of the number of proliferating centers on prognosis in myasthenia after thymectomy was nor demonstrated. Thymectomy in a generally accepted and most effective method of treatment in myasthenia.

摘要

本文描述了136例接受胸腺切除术治疗重症肌无力患者的疗效,这些患者在医院接受观察,并对其中107例进行了问卷调查,以了解10年后的远期结果。除合并胸腺瘤的重症肌无力患者外,治愈率为26.4%,显著改善率为19.6%,中度改善率为21.4%,运动强度改善率为27.1%,恶化率为3.8%。评估主要基于胆碱能药物的服用量。早期死亡率为2.4%,晚期死亡率为1.9%。讨论了术后并发症/呼吸及两种危象与死亡率的关系,以及术中胸膜损伤、手术方式和胸腺的解剖变异。未证实增殖中心数量对胸腺切除术后重症肌无力预后的影响。胸腺切除术是重症肌无力普遍接受且最有效的治疗方法。

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