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慢性酒精中毒所致充血性心力衰竭(作者译)

[Congestive heart failure due to chronic alcoholism (author's transl)].

作者信息

Tatibouet L, Tatibouet M H

出版信息

Sem Hop. 1982 Apr 22;58(16):991-6.

PMID:6283671
Abstract

In rare instances, chronic alcoholism leads to the congestive heart failure which is characteristic of alcoholic beriberi with edema. The affected patients is usually a young man with longstanding alcoholic intoxication and often with neurologic features. Onset is often sudden, with dyspnea on exertion, orthopnea, and palpitations. The clinical sings of cardiac failure are unequivocal. Roentgenography shows cardiomegaly mainly due to enlargement of the right cavities and of the pulmonary artery. ECG shows sinus tachycardia and abnormal repolarisation in the precordium. The cardiac output and the cardiac index are increased, as well as the coronary output. Pyruvic acid levels exceed 15 mg/l, the provoked hyperpyruvicemia test is abnormal, thiamine levels are low, and the tryptophane test is normal. The course is variable. Cardiac beriberi progresses by exacerbation and remissions. Prognosis is poor, with a risk of sudden death. However, with adequate treatment combining rest, a low sodium diet, alcohol withdrawal, diuretics, and vitamin B1 (IV) recovery occurs. Our two observations clearly fit this description.

摘要

在罕见情况下,慢性酒精中毒会导致充血性心力衰竭,这是伴有水肿的酒精性脚气病的特征。受影响的患者通常是一名长期酒精中毒的年轻男性,且常伴有神经学特征。发病往往突然,表现为劳力性呼吸困难、端坐呼吸和心悸。心力衰竭的临床体征明确。X线检查显示心脏扩大,主要是由于右心腔和肺动脉扩大。心电图显示窦性心动过速和心前区复极异常。心输出量、心脏指数以及冠状动脉血流量均增加。丙酮酸水平超过15mg/l,激发性高丙酮酸血症试验异常,硫胺素水平低,色氨酸试验正常。病程多变。心脏型脚气病呈加重与缓解交替进展。预后不良,有猝死风险。然而,通过休息、低钠饮食、戒酒、利尿剂和维生素B1(静脉注射)的适当联合治疗可实现康复。我们的两例观察结果显然符合这一描述。

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