Seidel L, Haupt I
Z Allg Mikrobiol. 1982;22(2):133-7. doi: 10.1002/jobm.3630220209.
Mutants with various levels of resistance to streptothricin were isolated from Escherichia coli K12, strain A19 after mutagenesis with N-methyl-N-nitro-N-nitroso-guanidine and ethylmethane-sulfonate. Nourseothricin, a mixture of streptothricin F and D was the selection agent. Spontaneous resistant mutants could not be found. The streptothricin-resistant mutant E. coli A19 Stcr 2/2/1 shows cross-resistance to some of the aminoglycoside antibiotics investigated, but no cross-resistance to chloramphenicol and chlortetracyclin. These results indicate similar mechanisms of action of streptothricin and aminoglycoside antibiotics.
用N-甲基-N-硝基-N-亚硝基胍和甲基磺酸乙酯诱变大肠杆菌K12菌株A19后，分离出了对链丝菌素具有不同抗性水平的突变体。制霉菌素（链丝菌素F和D的混合物）为选择剂。未发现自发抗性突变体。抗链丝菌素的突变体大肠杆菌A19 Stcr 2/2/1对所研究的一些氨基糖苷类抗生素表现出交叉抗性，但对氯霉素和金霉素无交叉抗性。这些结果表明链丝菌素和氨基糖苷类抗生素的作用机制相似。
