Baeva E A, Selezneva T S, Glinskaia E V, Auzinia A V, Rudakova Z A
Zh Mikrobiol Epidemiol Immunobiol. 1982 Feb(2):90-6.
The influence of the interval between injections of adsorbed DPT vaccine on the effectiveness of immunization has been studied. The intensity of antibody formation to the pertussis component has been found to decrease 2.7-3.7 times if the interval between the injections constituting the course of primary immunization is prolonged for more than 6 months. The interval between the course of primary immunization and the first booster injection, which lasts 1.5-2 years in accordance with the currently accepted immunization schedule, is unreasonably long. Immunological characteristics in respect to pertussis have been found to decrease 8-45 times as early as 16 months after the first booster injection. Most of the vaccines catching pertussis at that time had the moderately severe form of this infection.
已对吸附百白破疫苗注射间隔对免疫效果的影响进行了研究。如果构成初次免疫疗程的注射间隔延长超过6个月，发现针对百日咳成分的抗体形成强度会降低2.7至3.7倍。按照目前公认的免疫程序，初次免疫疗程与首次加强注射之间持续1.5至2年的间隔时间过长。已发现，早在首次加强注射后16个月，针对百日咳的免疫特性就会降低8至45倍。当时感染百日咳的大多数疫苗都呈这种感染的中度严重形式。
