Crandell R A, Mesfin G M, Mock R E
Am J Vet Res. 1982 Feb;43(2):326-8.
Pseudorabies virus (PRV) was not transmitted horizontally from 3 PRV-infected calves to 2 contact control calves during 4 days of comingling in experiment 1. Although these contact control calves developed clinical signs of pseudorabies when infected intranasally with PRV in experiment 2, they did not transmit PRV to a second pair of contact control calves. However, 1 of 2 pigs comingled with these 4 calves seroconverted. During both experiments, moderate amounts (10(2) to 10(5) TCID50) of PRV were present in the nasal secretions of the infected calves during the contact periods. All infected calves traumatized their nares or periorbital tissue. Infected calves developed a nonsuppurative meningoencephalitis mainly involving the brain stem. Four of the 5 infected calves had nonsuppurative ganglioneuritis and acute lymphoid necrosis of germinal centers. Virus could not be recovered from nasal and tonsillar swab samples from contact-control calves and pigs.
在实验1中，3头感染伪狂犬病病毒（PRV）的犊牛与2头接触对照犊牛混群4天，期间PRV未发生水平传播。尽管在实验2中，这些接触对照犊牛经鼻内感染PRV后出现了伪狂犬病的临床症状，但它们并未将PRV传播给另一对接触对照犊牛。然而，与这4头犊牛混群的2头猪中有1头发生了血清转化。在两个实验的接触期内，感染犊牛的鼻分泌物中均存在适量（10²至10⁵ TCID₅₀）的PRV。所有感染犊牛的鼻孔或眶周组织均有损伤。感染犊牛发生了主要累及脑干的非化脓性脑膜脑炎。5头感染犊牛中有4头出现了非化脓性神经节神经炎和生发中心急性淋巴样坏死。在接触对照犊牛和猪的鼻拭子和扁桃体拭子样本中未检测到病毒。
