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环核苷酸对皮肤中DNA合成的影响。

The influence of cyclic nucleotides on DNA synthesis in skin.

作者信息

Carney S A

出版信息

Br J Exp Pathol. 1982 Jun;63(3):351-3.

PMID:6284195
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2040637/
Abstract

Total saline-soluble protein, total DNA, and 3H-thymidine labelling of DNA were measured in cultured guinea-pig skin during a 3-day incubation period. An early rise in total soluble protein and a fall in total DNA indicated loss of the cells damaged in cutting the skin samples. Samples incubated with dibutyryl cyclic adenosine monophosphate (db cAMP) showed an early stimulation of DNA synthesis. Cyclic guanosine monophosphate (cGMP) stimulation of DNA synthesis showed a peak after 48 h incubation, probably reflecting a slower rate of entry of the compound into the epidermal cells.

摘要

在为期3天的孵育期内，对培养的豚鼠皮肤中的总盐溶性蛋白、总DNA以及DNA的3H-胸腺嘧啶核苷标记进行了测量。总可溶性蛋白的早期升高和总DNA的下降表明在切割皮肤样本时受损细胞的丢失。用二丁酰环磷酸腺苷（db cAMP）孵育的样本显示DNA合成受到早期刺激。环磷酸鸟苷（cGMP）对DNA合成的刺激在孵育48小时后出现峰值，这可能反映了该化合物进入表皮细胞的速度较慢。

相似文献

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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Dibutyryl cyclic AMP inhibition of epidermal cell division.二丁酰环磷腺苷对表皮细胞分裂的抑制作用
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The initiation of epidermal wound healing in cuts and burns.割伤和烧伤中表皮伤口愈合的起始过程。
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