铅精炼厂工人红细胞膜上钠钾ATP酶活性增加。
An increase in the Na+/K+-ATPase activity of erythrocyte membranes in workers employed in a lead refining factory.
作者信息
Karai I, Fukumoto K, Horiguchi S
出版信息
Br J Ind Med. 1982 Aug;39(3):290-4. doi: 10.1136/oem.39.3.290.
To clarify the relationship between erythrocyte Na+/K+-ATPase activity and haematological findings, several clinical laboratory examinations were performed on 31 male workers employed in a scrap lead refining factory and, as controls, 50 male workers employed in railway construction. The results were: (1) Values for erythrocyte Na+/K+-ATPase activity, blood and urine lead, urine delta-aminolaevulinic acid, and urine coproporphyrin of lead workers were significantly higher than those of the controls (p less than 0.01). (2) A strongly positive relationship between blood lead and erythrocyte Na/K-ATPase activity was observed in lead workers (r = 0.473, p less than 0.01). (3) A strongly negative relationship between Na+/K+-ATPase activity and intracellular sodium was observed in both groups (lead workers; r = -0.601, p less than 0.01: controls; r = 0.595, p less than 0.01).
为阐明红细胞钠钾ATP酶活性与血液学检查结果之间的关系，对31名从事废铅精炼厂工作的男性工人进行了多项临床实验室检查，并以50名从事铁路建设的男性工人作为对照。结果如下：（1）铅作业工人的红细胞钠钾ATP酶活性、血铅和尿铅、尿δ-氨基乙酰丙酸以及尿粪卟啉值均显著高于对照组（p<0.01）。（2）在铅作业工人中观察到血铅与红细胞钠钾ATP酶活性之间呈强正相关（r = 0.473，p<0.01）。（3）两组中均观察到钠钾ATP酶活性与细胞内钠之间呈强负相关（铅作业工人；r = -0.601，p<0.01；对照组；r = 0.595，p<0.01）。
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