铅接触工人红细胞渗透抵抗力增加的机制
Mechanism of increased osmotic resistance of red cells in workers exposed to lead.
作者信息
Karai I, Fukumoto K, Horiguchi S
出版信息
Br J Ind Med. 1982 May;39(2):153-6. doi: 10.1136/oem.39.2.153.
In order to clarify the mechanism of the increased osmotic resistance of red blood cells in lead workers 19 men employed in a lead refining factory and 18 control male workers employed in railway construction were examined for red cell count, haematocrit, MCV, blood and urine lead concentrations, urine coproporphyrin and delta-aminolevulinic acid, osmotic resistance of red cells, lecithin-cholesterol acyltransferase (LCAT) activity in serum, and cholesterol content and cholesterol-to-phospholipid ratio of the red cell membrane. The results were: (1) The osmotic resistance of the red cells (p less than 0.05), cholesterol content of the red cell membrane, blood and urine lead, urine coproporphyrin, and urine delta-ALA concentrations (p less than 0.01) were higher in the lead workers than in the controls. (2) In the lead workers close relationships were observed between the osmotic resistance and the blood lead concentration (r = -0.515, p less than 0.05), osmotic resistance and LCAT activity (r = 0.596, p less than 0.01), and osmotic resistance and cholesterol of the red cell membrane (r = -0.492, p less than 0.05).
为了阐明铅作业工人红细胞渗透压抵抗力增加的机制，对一家炼铅厂的19名男性工人和铁路建设行业的18名对照男性工人进行了检查，检测项目包括红细胞计数、血细胞比容、平均红细胞体积、血铅和尿铅浓度、尿中粪卟啉和δ-氨基乙酰丙酸、红细胞渗透压抵抗力、血清卵磷脂胆固醇酰基转移酶（LCAT）活性以及红细胞膜胆固醇含量和胆固醇与磷脂比值。结果如下：（1）铅作业工人的红细胞渗透压抵抗力（p<0.05）、红细胞膜胆固醇含量、血铅和尿铅、尿中粪卟啉以及尿δ-ALA浓度（p<0.01）均高于对照组。（2）在铅作业工人中，观察到渗透压抵抗力与血铅浓度（r = -0.515，p<0.05）、渗透压抵抗力与LCAT活性（r = 0.596，p<0.01）以及渗透压抵抗力与红细胞膜胆固醇（r = -0.492，p<0.05）之间存在密切关系。
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