Dardi L E, Ariano L, Ariano M C, Gould V E
Diagn Gynecol Obstet. 1982 Summer;4(2):127-32.
We studied a pronounced Arias-Stella reaction in an incomplete abortion curettage specimen; the gestational age was 8 weeks by size. The majority of cells in this reaction showed ground glass, eosinophilic nuclear "inclusions" simulating herpetic Cowdry type B nuclear inclusions. This was coupled with a history of herpetic stomatitis of the patient and her husband 2 weeks prior to the curettage, raising the question of viremia and transplacental herpetic endometrial infection. Immunoperoxidase staining using the PAP technique directed against Herpes simplex virus types 1 and 2 was negative. Ultrastructural analysis elucidated the true nature of the nuclear "inclusions" as pseudonuclear inclusions consisting of invaginations of cytoplasm within the nuclei. Viral particles were not found. We are unaware of any similar report, and present this case to suggest the possible differential diagnosis between herpetic endometritis with associated cytologic atypia and the Arias-Stella reaction.
我们研究了一例不完全流产刮宫标本中的显著阿rias-Stella反应；根据大小判断孕周为8周。该反应中的大多数细胞显示出毛玻璃样、嗜酸性核“包涵体”，类似于疱疹性B型考德里核内包涵体。这与患者及其丈夫在刮宫前2周患疱疹性口炎的病史相关，引发了病毒血症和经胎盘疱疹性子宫内膜感染的问题。使用针对1型和2型单纯疱疹病毒的PAP技术进行免疫过氧化物酶染色为阴性。超微结构分析阐明了核“包涵体”的真实性质，即由核内细胞质内陷形成的假核包涵体。未发现病毒颗粒。我们未意识到有任何类似报告，并呈现此病例以提示疱疹性子宫内膜炎伴相关细胞学异型性与阿rias-Stella反应之间可能的鉴别诊断。
