Svedersky L P, Hui A, May L, McKay P, Stebbing N
Eur J Immunol. 1982 Mar;12(3):244-7. doi: 10.1002/eji.1830120314.
Treatment of human peripheral blood lymphocytes with cloned N alpha-desacetylthymosin alpha 1 induced interferon production. The kinetics is similar to that of mitogen-induced interferon induction. N alpha-desacetylthymosin alpha 1, in combination with mitogen, augments the amount of interferon produced. This interferon is immune interferon (IFN-gamma) as determined by sensitivity to pH 2, lack of neutralization by antibodies to IFN-alpha or IFN-beta and absence of activity of MDBK cells. Although the mechanism of induction of IFN-gamma by N alpha-desacetylthymosin alpha 1 is unclear, this compound is not mitogenic at concentrations causing IFN-gamma production. These results indicate that thymic factors may also participate in the regulation of IFN-gamma-production.
用克隆的Nα-脱乙酰胸腺素α1处理人外周血淋巴细胞可诱导干扰素产生。其动力学与丝裂原诱导的干扰素诱导相似。Nα-脱乙酰胸腺素α1与丝裂原联合使用可增加干扰素的产生量。经对pH 2的敏感性、抗IFN-α或IFN-β抗体不能中和以及MDBK细胞无活性测定，这种干扰素为免疫干扰素（IFN-γ）。虽然Nα-脱乙酰胸腺素α1诱导IFN-γ的机制尚不清楚，但该化合物在引起IFN-γ产生的浓度下无促有丝分裂作用。这些结果表明胸腺因子也可能参与IFN-γ产生的调节。
