Lee S M
Diabetologia. 1982 May;22(5):349-53. doi: 10.1007/BF00253580.
Genetically diabetic mice (C57 BLKsJ db/db) aged 5-6 weeks were given a diet containing 20% by weight of non-nutritive bulk and compared with age matched control diabetic mice on a normal diet (fibre content 4.5%) and non-diabetic mice. The duration of study was 12 weeks. No adverse effects were observed in animals given the high fibre diet. Total food consumption was greater in mice receiving the fibre enriched diet, but their absolute caloric intake was 6% less than control diabetic mice. Both groups exhibited similar rates of growth and development. Water intake in the experimental diabetic mice was reduced and similar to that of normal non-diabetic mice. Fasting blood glucose was significantly decreased in the experimental diabetic mice at 12 weeks. Renal pathological lesions in the control diabetic mice showed glomerular mesangial expansion and deposition of immunoglobulins within the mesangium. The experimental diabetic animals exhibited significantly less renal pathology, including light and immunofluorescent lesions. It is concluded that addition of non-absorbable fibre to the diet of genetically diabetic mice improves glycaemic control and retards the development of diabetic nephropathy.
给5至6周龄的遗传性糖尿病小鼠（C57 BLKsJ db/db）喂食含有20%（按重量计）非营养性填充剂的饮食，并将其与年龄匹配的正常饮食（纤维含量4.5%）的对照糖尿病小鼠和非糖尿病小鼠进行比较。研究持续时间为12周。在给予高纤维饮食的动物中未观察到不良反应。接受富含纤维饮食的小鼠的总食物消耗量更大，但其绝对热量摄入量比对照糖尿病小鼠少6%。两组小鼠的生长和发育速率相似。实验性糖尿病小鼠的饮水量减少，与正常非糖尿病小鼠的饮水量相似。在12周时，实验性糖尿病小鼠的空腹血糖显著降低。对照糖尿病小鼠的肾脏病理损伤表现为肾小球系膜扩张和系膜内免疫球蛋白沉积。实验性糖尿病动物的肾脏病理变化明显较少，包括轻度和免疫荧光损伤。得出的结论是，在遗传性糖尿病小鼠的饮食中添加不可吸收纤维可改善血糖控制并延缓糖尿病肾病的发展。
