Harvey D J, Leuschner J T, Paton W D
J Chromatogr. 1982 Apr 30;239:243-50. doi: 10.1016/s0021-9673(00)81984-6.
Gas chromatography-mass spectrometry has been used to investigate the in vivo hepatic metabolism of delta 1-tetrahydrocannabinol (delta 1-THC) in the New Zealand white rabbit. Sixteen metabolites were identified and shown to be present in different relative amounts compared with the hepatic metabolites of delta 1-THC produced by other species. The metabolic profile was also different from that reported from rabbit urine particularly with regard to the lower relative concentrations of acidic metabolites in the liver. The pharmacokinetics of delta 1-THC has been studied in the rabbit using the recently developed GC-MS method based on metastable ion monitoring. This revealed a terminal plasma delta 1-THC half life ranging from 34.16 to 59.30 h (mean 46.75 h) after a single dose and THC fat/plasma ratio of 10(3)-10(4):1.
气相色谱-质谱联用技术已被用于研究新西兰白兔体内δ1-四氢大麻酚（δ1-THC）的肝脏代谢情况。共鉴定出16种代谢产物，与其他物种产生的δ1-THC肝脏代谢产物相比，它们的相对含量各不相同。其代谢谱也与兔尿中报道的不同，尤其是肝脏中酸性代谢产物的相对浓度较低。利用最近开发的基于亚稳离子监测的气相色谱-质谱联用方法，对兔体内δ1-THC的药代动力学进行了研究。结果显示，单次给药后，血浆中δ1-THC的终末半衰期为34.16至59.30小时（平均46.75小时），THC脂肪/血浆比值为10³-10⁴:1。
