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人类主要组织相容性复合体在细胞毒性T细胞对病毒感染细胞的反应中的作用。

The role of the human major histocompatibility complex in cytotoxic T-cell responses to virus-infected cells.

作者信息

Biddison W E

出版信息

J Clin Immunol. 1982 Jan;2(1):1-9. doi: 10.1007/BF00915971.

DOI:10.1007/BF00915971
PMID:6284788
Abstract

The human major histocompatibility complex (HLA) has been demonstrated to play two roles in the generation and expression of cytotoxic T-lymphocyte responses to virus-infected cells: (1) cytotoxic T cells can only recognize viral antigens in conjunction with antigens encoded by HLA-A and -B genes; and (2) HLA-linked genes may control the capacity to generate T-cell responses to a given virus or to virus in conjunction with particular self HLA-A and -B antigens. Analysis of T-cell responses generated in vivo to Epstein-Barr virus suggests that human T cells may recognize virus in conjunction with antigens other than the class I HLA polymorphic specificities.

摘要

人类主要组织相容性复合体（HLA）已被证明在针对病毒感染细胞的细胞毒性T淋巴细胞反应的产生和表达中发挥两种作用：（1）细胞毒性T细胞只能识别与HLA - A和 - B基因编码的抗原结合的病毒抗原；（2）与HLA相关的基因可能控制产生针对特定病毒或与特定自身HLA - A和 - B抗原结合的病毒的T细胞反应的能力。对体内针对爱泼斯坦 - 巴尔病毒产生的T细胞反应的分析表明，人类T细胞可能识别与I类HLA多态性特异性以外的抗原结合的病毒。

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本文引用的文献

1
Immunochemical evidence in two haplotypes for at least three D region-encoded molecules, D, L, and R.在两个单倍型中存在至少三种D区域编码分子（D、L和R）的免疫化学证据。
J Immunol. 1981 May;126(5):1713-6.
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HLA restriction of human cytotoxic T cells.人类细胞毒性T细胞的HLA限制
Springer Semin Immunopathol. 1980 May;3(1):3-22. doi: 10.1007/BF00199923.
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Interaction of cytotoxic T lymphocytes and target cells.细胞毒性T淋巴细胞与靶细胞的相互作用。
一群未表现出获得性免疫缺陷综合征症状的同性恋男性中的功能性T淋巴细胞免疫缺陷。
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Interleukin-2 enhances the depressed natural killer and cytomegalovirus-specific cytotoxic activities of lymphocytes from patients with the acquired immune deficiency syndrome.白细胞介素-2可增强获得性免疫缺陷综合征患者淋巴细胞中降低的自然杀伤细胞活性和巨细胞病毒特异性细胞毒性活性。
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Autologous mixed lymphocyte reaction in man: XV. Cellular and molecular basis of deficient autologous mixed lymphocyte response in insulin-dependent diabetes mellitus.人类自体混合淋巴细胞反应：十五。胰岛素依赖型糖尿病患者自体混合淋巴细胞反应缺陷的细胞和分子基础。
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Deficient autologous mixed lymphocyte reaction in Kaposi's sarcoma associated with deficiency of Leu-3+ responder T cells.与Leu-3 +反应性T细胞缺乏相关的卡波西肉瘤中自体混合淋巴细胞反应缺陷。
J Clin Invest. 1983 Feb;71(2):296-300. doi: 10.1172/jci110769.
7
Adult human glial cells can present target antigens to HLA-restricted cytotoxic T-cells.成年人类神经胶质细胞可以将靶抗原呈递给受HLA限制的细胞毒性T细胞。
J Neuroimmunol. 1990 Sep-Oct;29(1-3):203-11. doi: 10.1016/0165-5728(90)90163-h.
Prog Allergy. 1980;27:69-133.
4
Influenza virus-specific cytotoxic T cells are restricted by multiple HLA-A3-related self antigens: evidence for recognition of distinct self structures in conjunction with different foreign antigens.流感病毒特异性细胞毒性T细胞受多种HLA - A3相关自身抗原的限制：结合不同外来抗原识别不同自身结构的证据。
J Immunol. 1981 Dec;127(6):2231-5.
5
Family studies define a new histocompatibility locus, SB, between HLA-DR and GLO.家系研究在HLA - DR和GLO之间确定了一个新的组织相容性位点SB。
Nature. 1981 Oct 29;293(5835):745-7. doi: 10.1038/293745a0.
6
Nomenclature for factors of the HLA system, 1980.1980年HLA系统因子命名法。
Bull World Health Organ. 1980;58(6):945-8.
7
Evidence for a new segregant series of B cell antigens that are encoded in the HLA-D region and that stimulate secondary allogenic proliferative and cytotoxic responses.存在一系列新的B细胞抗原分离株的证据，这些抗原由HLA - D区域编码，并刺激二次同种异体增殖和细胞毒性反应。
J Exp Med. 1980 Sep 1;152(3):565-80. doi: 10.1084/jem.152.3.565.
8
Influenza virus-specific cytotoxic T lymphocytes recognize HLA-molecules. Blocking by monoclonal anti-HLA antibodies.流感病毒特异性细胞毒性T淋巴细胞识别HLA分子。被单克隆抗HLA抗体阻断。
J Exp Med. 1980 Aug 1;152(2 Pt 2):195s-203s.
9
T cell subpopulations required for the human cytotoxic T lymphocyte response to influenza virus: evidence for T cell help.人类细胞毒性T淋巴细胞对流感病毒应答所需的T细胞亚群：T细胞辅助的证据
J Immunol. 1981 Aug;127(2):487-91.
10
Biological properties of an influenza A virus-specific killer T cell clone. Inhibition of virus replication in vivo and induction of delayed-type hypersensitivity reactions.甲型流感病毒特异性杀伤性T细胞克隆的生物学特性。体内病毒复制的抑制及迟发型超敏反应的诱导。
J Exp Med. 1981 Aug 1;154(2):225-34. doi: 10.1084/jem.154.2.225.