人类细胞毒性T细胞对流感病毒反应特异性的HLA连锁基因控制
HLA-linked genetic control of the specicity of human cytotoxic T-cell responses to influenza virus.
作者信息
Shaw S, Biddison W E
出版信息
J Exp Med. 1979 Mar 1;149(3):565-75. doi: 10.1084/jem.149.3.565.
Abstract
We have investigated elements of the genetic control of human in vitro cytotoxic T-cell responses to influenza virus-infected autologous cells by studies of a large family. The pattern of virus-immune cytotoxicity among siblings demonstrated T-cell recognition of influenza virus predominantly (greater than 90%) in association with determinants which are coded by genes linked to HLA (P less than 0.0002). Many family members consistently generated cytotoxic activity against influenza predominantly in association with antigens coded by genes of only one of their HLA haplotypes. Such haplotype preferences were consistent among HLA-identical siblings, indicating that the specificity of the T-cell response to influenza virus in association with HLA-A and -B antigens is controlled by genes linked to HLA.
摘要
我们通过对一个大家族的研究，调查了人类体外细胞毒性T细胞对流感病毒感染的自体细胞反应的遗传控制因素。兄弟姐妹之间病毒免疫细胞毒性的模式表明，T细胞对流感病毒的识别主要（超过90%）与由与HLA相关的基因编码的决定簇相关（P小于0.0002）。许多家庭成员始终主要针对仅由其一个HLA单倍型的基因编码的抗原产生针对流感的细胞毒性活性。这种单倍型偏好在HLA相同的兄弟姐妹中是一致的，表明与HLA - A和 - B抗原相关的T细胞对流感病毒反应的特异性由与HLA相关的基因控制。
相似文献
1
HLA-linked genetic control of the specicity of human cytotoxic T-cell responses to influenza virus.人类细胞毒性T细胞对流感病毒反应特异性的HLA连锁基因控制
J Exp Med. 1979 Mar 1;149(3):565-75. doi: 10.1084/jem.149.3.565.
2
The role of the human major histocompatibility complex in cytotoxic T-cell responses to virus-infected cells.人类主要组织相容性复合体在细胞毒性T细胞对病毒感染细胞的反应中的作用。
J Clin Immunol. 1982 Jan;2(1):1-9. doi: 10.1007/BF00915971.
3
4
Differences in HLA antigen recognition by human influenza virus-immune cytotoxic T cells.人类流感病毒免疫细胞毒性T细胞对HLA抗原识别的差异。
J Immunol. 1979 May;122(5):1705-9.
5
6
HLA restriction of secondary mumps-specific cytotoxic T lymphocytes.腮腺炎特异性细胞毒性T淋巴细胞的HLA限制
J Immunol. 1982 Aug;129(2):844-9.
7
Cloned lines of human cytotoxic T lymphocytes with specificity for influenza virus.对流感病毒具有特异性的人细胞毒性T淋巴细胞克隆系。
J Immunol. 1982 Oct;129(4):1731-5.
8
Human cytotoxic T-cell responses to type A and type B influenza viruses can be restricted by different HLA antigens. Implications for HLA polymorphism and genetic regulation.人类细胞毒性T细胞对甲型和乙型流感病毒的反应可能受到不同HLA抗原的限制。对HLA多态性和基因调控的影响。
J Exp Med. 1980 Jan 1;151(1):235-45. doi: 10.1084/jem.151.1.235.
9
HLA restriction of human cytotoxic T lymphocytes specific for influenza virus. Poor recognition of virus associated with HLA A2.针对流感病毒的人类细胞毒性T淋巴细胞的HLA限制。与HLA A2相关的病毒识别能力较差。
J Exp Med. 1978 Dec 1;148(6):1458-67. doi: 10.1084/jem.148.6.1458.
10
Influenza virus-specific cytotoxic T lymphocytes recognize HLA-molecules. Blocking by monoclonal anti-HLA antibodies.流感病毒特异性细胞毒性T淋巴细胞识别HLA分子。被单克隆抗HLA抗体阻断。
J Exp Med. 1980 Aug 1;152(2 Pt 2):195s-203s.
引用本文的文献
1
Quantitative genetics in the study of virus-induced disease.病毒诱导疾病研究中的数量遗传学。
Adv Virus Res. 2014;88:193-225. doi: 10.1016/B978-0-12-800098-4.00004-0.
2
Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.合作杂交群体中宿主遗传调控流感发病机制的建模。
PLoS Pathog. 2013 Feb;9(2):e1003196. doi: 10.1371/journal.ppat.1003196. Epub 2013 Feb 28.
3
A public HLA antigen associated with HLA-A9, Aw32, and Bw4.与 HLA-A9、Aw32 和 Bw4 相关的公共 HLA 抗原。
Immunogenetics. 1980;10(5):433-42. doi: 10.1007/BF01572579.
4
The role of host genetics in susceptibility to influenza: a systematic review.宿主遗传学在流感易感性中的作用：系统评价。
PLoS One. 2012;7(3):e33180. doi: 10.1371/journal.pone.0033180. Epub 2012 Mar 15.
5
In vitro induction of cytotoxic T lymphocytes against HTLV-I-infected T-cells from adult T-cell leukemia patients, asymptomatic HTLV-I carriers and seronegative healthy donors.体外诱导细胞毒性T淋巴细胞以对抗来自成人T细胞白血病患者、无症状HTLV-I携带者和血清阴性健康供体的HTLV-I感染的T细胞。
Jpn J Cancer Res. 1995 Jan;86(1):21-7. doi: 10.1111/j.1349-7006.1995.tb02983.x.
6
Cytotoxic lymphocytes and antibody-dependent complement-mediated cytotoxicity induced by administration of influenza vaccine.接种流感疫苗诱导的细胞毒性淋巴细胞和抗体依赖性补体介导的细胞毒性作用
Infect Immun. 1980 Nov;30(2):362-9. doi: 10.1128/iai.30.2.362-369.1980.
7
HLA restriction of human cytotoxic T cells.人类细胞毒性T细胞的HLA限制
Springer Semin Immunopathol. 1980 May;3(1):3-22. doi: 10.1007/BF00199923.
8
Human leukocyte antigen-linked genetic controls for T cell-mediated cytotoxic response to mumps virus in humans.人类白细胞抗原相关的基因控制人类对腮腺炎病毒的T细胞介导的细胞毒性反应。
Infect Immun. 1982 Feb;35(2):600-4. doi: 10.1128/iai.35.2.600-604.1982.
9
The human cytotoxic T cell response to influenza A vaccination.人类对甲型流感疫苗接种的细胞毒性T细胞反应。
Clin Exp Immunol. 1981 Feb;43(2):276-84.
10
Some newly recognized aspects of resistance against and recovery from influenza.流感抵抗与恢复的一些新认识的方面。
Arch Virol. 1982;73(3-4):207-17. doi: 10.1007/BF01318075.
本文引用的文献
1
Disquisitions of Original Antigenic Sin. I. Evidence in man.原始抗原罪的研究。一、人类证据。
J Exp Med. 1966 Sep 1;124(3):331-45. doi: 10.1084/jem.124.3.331.
2
Multiple H-2 linked immune response gene control of H-2 D-associated T-cell-mediated lympholysis to trinitrophenyl-modified autologous cells: Ir-like genes mapping to the left of I-A and within the I region.H-2 D相关的T细胞介导的对三硝基苯基修饰的自体细胞的淋巴细胞溶解的多个H-2连锁免疫反应基因控制：定位于I-A左侧和I区内的类Ir基因。
J Exp Med. 1976 Dec 1;144(6):1701-6. doi: 10.1084/jem.144.6.1701.
3
Nonrandom inclusion of H-2K and H-2D antigens in Friend virus particles from mice of various strains.来自不同品系小鼠的弗氏病毒颗粒中H-2K和H-2D抗原的非随机包含。
J Exp Med. 1978 Feb 1;147(2):340-51. doi: 10.1084/jem.147.2.340.
4
Human cell-mediated cytotoxicity against modified target cells is restricted by HLA.人类细胞介导的针对修饰靶细胞的细胞毒性受人类白细胞抗原（HLA）限制。
Nature. 1977 Dec 8;270(5637):526-8. doi: 10.1038/270526a0.
5
HLA restriction of cell-mediated lysis of influenza virus-infected human cells.流感病毒感染的人类细胞的细胞介导裂解的HLA限制
Nature. 1977 Dec 8;270(5637):524-6. doi: 10.1038/270524a0.
6
Cytotoxic T-cell responses to H-Y: mapping of the Ir genes.细胞毒性T细胞对H-Y的反应：Ir基因图谱分析
J Exp Med. 1978 Mar 1;147(3):758-67. doi: 10.1084/jem.147.3.758.
7
Y-antigen killing by T cells of women is restricted by HLA.女性T细胞对Y抗原的杀伤作用受HLA限制。
Nature. 1977 Apr 7;266(5602):544-5. doi: 10.1038/266544a0.
8
Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness.H-2复合体中的Ir基因调控抗病毒细胞毒性T细胞的产生。定位到K或D以及无反应性的显性现象。
J Exp Med. 1978 Aug 1;148(2):592-606. doi: 10.1084/jem.148.2.592.
9
Mapping of H-2 genes associated with T cell-mediated cytotoxic responses to SV40-tumour-associated specific antigens.与T细胞介导的针对SV40肿瘤相关特异性抗原的细胞毒性反应相关的H-2基因图谱分析。
Nature. 1978 Aug 17;274(5672):691-3. doi: 10.1038/274691a0.
10
Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype.感染流感病毒和痘苗病毒的小鼠体内的细胞毒性T细胞反应强度因H-2基因型而异。
J Exp Med. 1978 Aug 1;148(2):534-43. doi: 10.1084/jem.148.2.534.
Zotero 插件